23339

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2139428..2139930 Replicon chromosome
Accession NC_011741
Organism Escherichia coli IAI1

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag ECIAI1_RS10550 Protein ID WP_000767829.1
Coordinates 2139428..2139682 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag ECIAI1_RS10555 Protein ID WP_001259255.1
Coordinates 2139679..2139930 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECIAI1_RS10525 2134443..2134670 - 228 WP_000985273.1 sulfurtransferase TusA family protein -
ECIAI1_RS10530 2134684..2135742 - 1059 WP_000492335.1 transport protein YeeE -
ECIAI1_RS10535 2135921..2137279 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
ECIAI1_RS25165 2137269..2137331 - 63 WP_010723108.1 membrane protein YoeI -
ECIAI1_RS10540 2137546..2138475 - 930 WP_000803351.1 LysR family transcriptional regulator -
ECIAI1_RS10545 2138521..2139345 - 825 WP_000754763.1 SDR family oxidoreductase -
ECIAI1_RS10550 2139428..2139682 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
ECIAI1_RS10555 2139679..2139930 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
ECIAI1_RS23770 2140213..2140263 + 51 WP_001364200.1 his operon leader peptide -
ECIAI1_RS10560 2140409..2141308 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
ECIAI1_RS10565 2141314..2142618 + 1305 WP_001317939.1 histidinol dehydrogenase -
ECIAI1_RS10570 2142615..2143685 + 1071 WP_000108941.1 histidinol-phosphate transaminase -
ECIAI1_RS10575 2143685..2144752 + 1068 WP_000080060.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T23339 WP_000767829.1 NC_011741:c2139682-2139428 [Escherichia coli IAI1]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T23339 NC_011741:c2139682-2139428 [Escherichia coli IAI1]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT23339 WP_001259255.1 NC_011741:c2139930-2139679 [Escherichia coli IAI1]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT23339 NC_011741:c2139930-2139679 [Escherichia coli IAI1]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References