Detailed information of TA system TA233355

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 2337152..2337821
• Replicon: chromosome
• Accession: NZ_CP091456
• Organism: Avibacterium sp. 20-132

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: L4F93_RS11170
• Protein ID: WP_250350306.1
• Coordinates: 2337459..2337821 (-)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: L4F93_RS11165
• Protein ID: WP_250350305.1
• Coordinates: 2337152..2337454 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L4F93_RS11135 (L4F93_11135)	2334109..2334717	-	609	WP_250350300.1	tail assembly protein	-
L4F93_RS11140 (L4F93_11140)	2334660..2335403	-	744	WP_250350301.1	C40 family peptidase	-
L4F93_RS11145 (L4F93_11145)	2335465..2335743	+	279	WP_250351695.1	type II toxin-antitoxin system RelE/ParE family toxin	-
L4F93_RS11150 (L4F93_11150)	2335754..2336059	+	306	WP_250350302.1	HigA family addiction module antitoxin	-
L4F93_RS11155 (L4F93_11155)	2336056..2336769	-	714	WP_250350303.1	phage minor tail protein L	-
L4F93_RS11160 (L4F93_11160)	2336827..2337105	-	279	WP_250350304.1	hypothetical protein	-
L4F93_RS11165 (L4F93_11165)	2337152..2337454	-	303	WP_250350305.1	XRE family transcriptional regulator	Antitoxin
L4F93_RS11170 (L4F93_11170)	2337459..2337821	-	363	WP_250350306.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L4F93_RS11175 (L4F93_11175)	2337933..2338763	-	831	WP_250350307.1	phage antirepressor N-terminal domain-containing protein	-
L4F93_RS11180 (L4F93_11180)	2339305..2339658	-	354	WP_250350308.1	hypothetical protein	-
L4F93_RS11185 (L4F93_11185)	2339669..2340097	-	429	WP_250350309.1	hypothetical protein	-
L4F93_RS11190 (L4F93_11190)	2340232..2340369	-	138	WP_165381770.1	hypothetical protein	-
L4F93_RS11195 (L4F93_11195)	2340550..2341068	-	519	WP_250350310.1	phage antirepressor N-terminal domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2284324..2379487	95163

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (16-111)

Antitoxin

• HigA2-like, helix-turn-helix domain (9-89)

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13980.14 Da
• Isoelectric Point: 4.7909

>T233355 WP_250350306.1 NZ_CP091456:c2337821-2337459 [Avibacterium sp. 20-132]
MKQEWEVILQDPLLSWFDTLAEDDLLKVYAALELLSTEGPQLGRPYADTLQGSKYTNLKELRVQSKLSVFRLFYLFDPIR
QAIVLCGGDKKGKKEKLFYKEMIALAEKTYEDYLSEFSKE

Nucleotide

• Length: 363 bp

>T233355 NZ_HG813240:c1575976-1575575 [Mycobacterium tuberculosis 49-02]
ATGATCCTTGTCGACTCCGATGTGCTGATCGCGCATTTGCGGGGTGTCGTTGCTGCTCGCGATTGGCTTGTCAGCGCCCG
CAAGGACGGACCGCTGGCGATCAGCGTGGTGTCCACCGCCGAACTCATCGGCGGAATGCGGACCGCCGAACGGCGCGAGG
TGTGGCGCCTGCTTGCATCGTTTCGGGTACAGCCAGCAACCGAGGTAATCGCACGCCGCGCCGGCGACATGATGCGCCGA
TATCGTCGCAGCCACAACCGGATTGGACTTGGCGACTATCTGATAGCTGCTACCGCCGACGTCCAGGACCTGCAATTGGC
AACCCTCAACGTGTGGCATTTCCCCATGTTCGAGCAGCTGAAACCACCATTTGCGGTGCCGGGGCACCGACCGCGGGCAT
GA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11215.19 Da
• Isoelectric Point: 9.5655

>AT233355 WP_250350305.1 NZ_CP091456:c2337454-2337152 [Avibacterium sp. 20-132]
MSVAFKDLMSKLPAEKQAKVKAMADDMRMELQLYRIREELELSQKQMAEALNISQPSVVALEKRGNDIKLSSVKRYIEAM
GGVLNLSVELPTGKTVTFNL

Nucleotide

• Length: 303 bp

>AT233355 NZ_HG813240:c1576230-1575973 [Mycobacterium tuberculosis 49-02]
ATGAAGCGGACCAACATCTACCTCGACGAGGAGCAGACGGCAAGCCTCGACAAGTTGGCCGCGCAAGAAGGTGTTTCGCG
CGCCGAGCTGATCCGCCTCCTGCTGAACCGAGCCCTCACCACCGCTGGGGACGACCTTGCATCGGACCTGCAGGCTATAA
ACGATTCGTTCGGCACGCTTCGCCACCTGGATCCGCCGGTGCGTCGCTCCGGTGGTCGTGAACAGCACCTTGCCCAGGTG
TGGCGCGCCACCTCATGA