Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2235394..2235986 Replicon chromosome
Accession NZ_CP091456
Organism Avibacterium sp. 20-132

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag L4F93_RS10700 Protein ID WP_250350232.1
Coordinates 2235708..2235986 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag L4F93_RS10695 Protein ID WP_103852818.1
Coordinates 2235394..2235690 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L4F93_RS10670 (L4F93_10670) 2230759..2232207 + 1449 WP_250350228.1 sulfatase-like hydrolase/transferase -
L4F93_RS10675 (L4F93_10675) 2232744..2233292 - 549 WP_250350229.1 HAD family hydrolase -
L4F93_RS10680 (L4F93_10680) 2233297..2234232 - 936 WP_250350230.1 KpsF/GutQ family sugar isomerase -
L4F93_RS10690 (L4F93_10690) 2234791..2235240 - 450 WP_250350231.1 macrodomain Ter protein MatP -
L4F93_RS10695 (L4F93_10695) 2235394..2235690 - 297 WP_103852818.1 HigA family addiction module antitoxin Antitoxin
L4F93_RS10700 (L4F93_10700) 2235708..2235986 - 279 WP_250350232.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L4F93_RS10705 (L4F93_10705) 2236122..2237885 + 1764 WP_250350233.1 Lon protease family protein -
L4F93_RS10710 (L4F93_10710) 2238148..2238681 + 534 WP_250350234.1 bifunctional 3-hydroxydecanoyl-ACP dehydratase/trans-2-decenoyl-ACP isomerase -
L4F93_RS10715 (L4F93_10715) 2238742..2239224 - 483 WP_250350235.1 Cys-tRNA(Pro) deacylase -
L4F93_RS10720 (L4F93_10720) 2239298..2240272 + 975 WP_250350236.1 oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-65)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10838.39 Da        Isoelectric Point: 9.1907

>T233353 WP_250350232.1 NZ_CP091456:c2235986-2235708 [Avibacterium sp. 20-132]
MITHFSCKETQAFFEGKRIRRFIAFEKVATRKLQQLNAATELNFLKIPPGNHLEQLSGDRKGQYSIRINDQWRICFTWLN
GHATDVEIVDYH

Download         Length: 279 bp

>T233353 NZ_HG813240:c1388855-1388562 [Mycobacterium tuberculosis 49-02]
GTGAGCGACGACCATCCCTACCACGTGGCGATCACCGCGACAGCGGCACGCGACCTGCAACGCTTACCCGAAAAGATCGC
CGCCGCATGTGTCGAGTTTGTTTTCGGACCGCTGCTTAACAACCCGCATAGGTTGGGCAAGCCGCTGCGCAATGACCTTG
AAGGCCTCCACTCAGCCCGCCGCGGTGATTACCGCGTCGTCTACGCCATCGACGACGGCCACCACCGAGTCGAGATCATC
CACATCGCTCGTCGCAGTGCCAGCTACCGAATGAACCCGTGCCGGCCACGTTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11174.83 Da        Isoelectric Point: 6.7234

>AT233353 WP_103852818.1 NZ_CP091456:c2235690-2235394 [Avibacterium sp. 20-132]
MIREIPLSHPGEILLEDWLKPLGISQYALAKAISVPPRRINEIVKGKRSITPDTALRLATFFGTDAQSWLNMQSHYDTEQ
TRSIINEDLSHIIPYQFA

Download         Length: 297 bp

>AT233353 NZ_HG813240:c1389121-1388852 [Mycobacterium tuberculosis 49-02]
ATGGCTGTTGTCCCACTGGGCGAAGTCCGCAATCGCCTCTCTGAGTACGTCGCCGAAGTTGAGCTGACACACGAGCGCAT
CACGATAACCCGGCACGGTCATCCGGCGGCGGTATTGATCTCGGCCGATGACCTGGCGTCCATCGAGGAAACGCTGGAGG
TGCTACGCACCCCTGGCGCCAGCGAGGCCATTCGTGAAGGCCTCGCCGATGTTGCCGCAGGGCGCTTCGTGAGCAACGAC
GAGATCCGCAACCGTTACACCGCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References