Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 2202977..2203627 Replicon chromosome
Accession NZ_CP091456
Organism Avibacterium sp. 20-132

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag L4F93_RS10555 Protein ID WP_250350208.1
Coordinates 2202977..2203309 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag L4F93_RS10560 Protein ID WP_250350209.1
Coordinates 2203313..2203627 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L4F93_RS10535 (L4F93_10535) 2198771..2199724 - 954 WP_250350204.1 thioredoxin-disulfide reductase -
L4F93_RS10540 (L4F93_10540) 2199781..2200632 - 852 WP_250350205.1 co-chaperone YbbN -
L4F93_RS10545 (L4F93_10545) 2200748..2202097 - 1350 WP_250350206.1 GntP family permease -
L4F93_RS10550 (L4F93_10550) 2202377..2202901 + 525 WP_250350207.1 gluconokinase -
L4F93_RS10555 (L4F93_10555) 2202977..2203309 + 333 WP_250350208.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L4F93_RS10560 (L4F93_10560) 2203313..2203627 + 315 WP_250350209.1 helix-turn-helix domain-containing protein Antitoxin
L4F93_RS10565 (L4F93_10565) 2203732..2205660 + 1929 WP_250350210.1 ABC transporter ATP-binding protein -
L4F93_RS10570 (L4F93_10570) 2205845..2207704 - 1860 WP_250350211.1 1-deoxy-D-xylulose-5-phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(10-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(42-92)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12748.84 Da        Isoelectric Point: 9.9061

>T233352 WP_250350208.1 NZ_CP091456:2202977-2203309 [Avibacterium sp. 20-132]
MKAVFIELPFFEKYRKEYLSDDEYLMLQNELLVAPEKGDLIQGTGGLRKLRIANSKRNRGKRGGARVIYYYYVRNAAIYF
LTAYGKEMKEDLTADEKSILAKIVENIKGK

Download         Length: 333 bp

>T233352 NZ_HG813240:1384517-1384948 [Mycobacterium tuberculosis 49-02]
GTGATCATCCCTGACATCAATCTGCTGCTCTACGCGGTCATCACCGGATTCCCGCAGCACCGGCGCGCGCATGCGTGGTG
GCAAGACACCGTCAACGGCCACACCCGTATCGGGCTGACGTATCCGGCGTTGTTCGGGTTCCTACGGATCGCCACCAGTG
CCCGCGTGCTCGCCGCGCCACTGCCAACCGCGGATGCGATCGCCTATGTGCGCGAGTGGCTTTCGCAGCCGAACGTGGAC
CTACTCACGGCGGGTCCGCGCCACCTGGACATCGCGTTGGGCCTGCTCGACAAGCTCGGCACAGCCAGCCACCTAACCAC
CGATGTGCAACTGGCCGCCTACGGCATCGAATACGACGCCGAGATCCATTCCAGTGACACCGACTTTGCCCGATTCGCCG
ATCTGAAGTGGACCGACCCGTTGCGCGAATAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12008.86 Da        Isoelectric Point: 8.5686

>AT233352 WP_250350209.1 NZ_CP091456:2203313-2203627 [Avibacterium sp. 20-132]
MERNLFEELKQGLEQMQVHLEGKTTLKTIERELPAEMGEISANEVKSIREKLNLSQSVFAKKLRMSVRTYQGWEQGKTTP
NKQATLLLKMIERSPQTFEDIASL

Download         Length: 315 bp

>AT233352 NZ_HG813240:1384260-1384520 [Mycobacterium tuberculosis 49-02]
ATGCGCACCACCTTGACGCTCGATGACGACGTCGTCCGGCTGGTCGAAGACGCAGTGCATCGCGAACGCCGCCCGATGAA
GCAGGTCATCAACGATGCGCTGCGCAGAGCGCTGGCGCCGCCGGTGAAACGGCAGGAGCAGTATCGGTTGGAGCCGCATG
AGTCGGCTGTGCGTTCCGGGTTGGATCTGGCCGGCTTCAACAAGTTGGCCGACGAACTGGAGGATGAGGCGCTGCTGGAT
GCCACGCGTCGGGCCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References