Detailed information of TA system TA233351

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 2137580..2138240
• Replicon: chromosome
• Accession: NZ_CP091456
• Organism: Avibacterium sp. 20-132

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: L4F93_RS10240
• Protein ID: WP_250350148.1
• Coordinates: 2137881..2138240 (-)
• Length: 120 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: L4F93_RS10235
• Protein ID: WP_250350147.1
• Coordinates: 2137580..2137879 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L4F93_RS10215 (L4F93_10215)	2133735..2134529	+	795	WP_250350144.1	helical backbone metal receptor	-
L4F93_RS10220 (L4F93_10220)	2134526..2135506	+	981	WP_250351683.1	iron ABC transporter permease	-
L4F93_RS10225 (L4F93_10225)	2135499..2136296	+	798	WP_250350145.1	ABC transporter ATP-binding protein	-
L4F93_RS10230 (L4F93_10230)	2136371..2137537	+	1167	WP_250350146.1	PD-(D/E)XK nuclease family protein	-
L4F93_RS10235 (L4F93_10235)	2137580..2137879	-	300	WP_250350147.1	helix-turn-helix transcriptional regulator	Antitoxin
L4F93_RS10240 (L4F93_10240)	2137881..2138240	-	360	WP_250350148.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L4F93_RS10245 (L4F93_10245)	2138331..2142020	-	3690	WP_250350149.1	methionine synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	ompP5	2028478..2180241	151763

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (17-110)

Antitoxin

• Cro/C1-type helix-turn-helix domain (32-80)

Sequences

Toxin

Protein

• Length: 120 a.a.
• Molecular weight: 13705.87 Da
• Isoelectric Point: 9.9504

>T233351 WP_250350148.1 NZ_CP091456:c2138240-2137881 [Avibacterium sp. 20-132]
MTKPQHWNVILTDNFVAWLKQQNNAIQEDVTAALLLLKTVGPELSRPYADTLKGSQYPNMKELRIQHQGKPLRALFAFDP
LRQAIILCAGDKSNDKQFYKRMIKQADAEFSAYLRTLEK

Nucleotide

• Length: 360 bp

>T233351 NZ_HG813240:1238230-1238604 [Mycobacterium tuberculosis 49-02]
GTGATCCTGGTCGACACTTCGGTATGGATTGAGCACCTGCGCGCCGCCGACGCGCGACTCGTCGAGCTGCTGGGCGATGA
CGAGGCCGGTTGCCATCCGCTCGTCATCGAGGAGCTGGCGCTTGGCTCGATCAAGCAGCGAGACGTTGTTCTCGATCTGT
TGGCCAACCTCTACCAGTTTCCGGTGGTGACCCACGACGAAGTGTTGCGGCTTGTCGGTCGGCGGCGGTTGTGGGGTCGG
GGACTCGGTGCCGTCGATGCCAACCTTCTTGGTTCGGTGGCTCTGGTTGGCGGCGCGCGACTATGGACGCGGGACAAGCG
GTTGAAGGCGGCGTGCGCGGAAAGCGGTGTTGCGCTGGCTGAGGAAGTGTCCTGA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11204.94 Da
• Isoelectric Point: 4.7162

>AT233351 WP_250350147.1 NZ_CP091456:c2137879-2137580 [Avibacterium sp. 20-132]
MKTLEQLLDEFSPEARQRIEQKAEELLLESGLSSIRQEMEISQKQLADALGISQPAVAQIEQRGNELRLSTLKRYVETMG
GKLSLAIDMPMGETRIFKI

Nucleotide

• Length: 300 bp

>AT233351 NZ_HG813240:1238036-1238233 [Mycobacterium tuberculosis 49-02]
ATGAGGACGACGGTGACCGTTGACGACGCCTTGTTAGCCAAAGCGGCCGAATTGACTGGGGTGAAAGAGAAGTCGACGCT
CCTGCGCGAGGGGTTGCAGACACTGGTCCGGGTGGAGAGCGCCCGGCGGTTGGCGGCTCTCGGCGGCACCGACCCGCAAG
CTACCGCGGCGCCGAGACGCCGGACGTCGCCCCGGTGA