Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1382475..1383110 Replicon chromosome
Accession NZ_CP091456
Organism Avibacterium sp. 20-132

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag L4F93_RS06575 Protein ID WP_250349558.1
Coordinates 1382475..1382780 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag L4F93_RS06580 Protein ID WP_250351645.1
Coordinates 1382790..1383110 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L4F93_RS06565 (L4F93_06565) 1379048..1380706 + 1659 WP_250349556.1 putative transporter -
L4F93_RS06570 (L4F93_06570) 1380946..1382331 + 1386 WP_250349557.1 outer membrane protein transport protein -
L4F93_RS06575 (L4F93_06575) 1382475..1382780 + 306 WP_250349558.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L4F93_RS06580 (L4F93_06580) 1382790..1383110 + 321 WP_250351645.1 HigA family addiction module antitoxin Antitoxin
L4F93_RS06585 (L4F93_06585) 1383157..1383696 + 540 WP_250349559.1 methylated-DNA--[protein]-cysteine S-methyltransferase -
L4F93_RS06590 (L4F93_06590) 1383728..1384405 + 678 WP_250349560.1 DNA mismatch repair endonuclease MutH -
L4F93_RS06595 (L4F93_06595) 1384478..1385200 + 723 WP_250349561.1 TerC family protein -
L4F93_RS06600 (L4F93_06600) 1385296..1385763 - 468 WP_250349562.1 surface-adhesin E family protein -
L4F93_RS06605 (L4F93_06605) 1385997..1387034 + 1038 WP_250349563.1 phosphoribosylformylglycinamidine cyclo-ligase -
L4F93_RS06610 (L4F93_06610) 1387034..1387672 + 639 WP_250349564.1 phosphoribosylglycinamide formyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(7-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 12108.89 Da        Isoelectric Point: 9.5601

>T233348 WP_250349558.1 NZ_CP091456:1382475-1382780 [Avibacterium sp. 20-132]
VFNLTAKHFKDDYLYRFFQYGELHSKIPANLAKVLARKLDMINAAENLNDLRVPPANRLELLEPKENKRYSIRVNKQYRL
IFHFDNGELSQLYLDPHRYDL

Download         Length: 306 bp

>T233348 NZ_HG813240:840141-840569 [Mycobacterium tuberculosis 49-02]
ATGTTCCTTCTCGACGCCAACGTGCTGCTGGCTGCACACCGCGGTGACCACCCGAATCACCGAACCGTCCGCCCCTGGTT
CGATCGACTGCTCGCGGCTGACGACCCCTTCACAGTGCCGAACCTGGTATGGGCGTCGTTCCTCCGGCTGGCAACGAATC
GACGCATCTTCGAGATTCCGTCACCGCGAGCAGAGGCATTCGCATTCGTCGAAGCCGTCACCGCCCAGCCCCATCACCTT
CCGACGAACCCCGGTCCCAGACACCTCATGCTGCTGCGAAAACTCTGCGACGAGGCCGACGCATCGGGCGACTTGATACC
TGACGCGGTACTCGCGGCCATAGCAGTGGGGCATCACTGCGCCGTGGTGAGCCTGGACAGGGATTTCGCCCGGTTTGCCT
CGGTGCGCCACATTCGCCCGCCGCTCTAG

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12242.05 Da        Isoelectric Point: 9.7685

>AT233348 WP_250351645.1 NZ_CP091456:1382790-1383110 [Avibacterium sp. 20-132]
MFSTQRKPTSVGEVLQEEFLHPLNLKISDLAEILDVHRNTASSLVNNHSKVTLEMAVKLAKAFGTSPEFWINLQHNLDLW
ELKHNARFQQRLDKVKIANYRPTFSV

Download         Length: 321 bp

>AT233348 NZ_HG813240:839860-840117 [Mycobacterium tuberculosis 49-02]
ATGCGCACCACGGTGTCAATCTCCGATGAAATACTCGCTGCCGCCAAACGCCGGGCCCGCGAGCGTGGTCAATCGCTGGG
CGCTGTGATCGAGGACGCCCTTCGGCGGGAGTTCGCCGCCGCCCACGTCGGCGGCGCCCGCCCGACCGTCCCGGTTTTCG
ACGGCGGCACCGGTCCGCGGCGAGGCATCGACCTGACCTCGAATAGAGCGTTGTCCGAAGTGCTCGACGAGGGCCTGGAA
CTGAACTCCCGGAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References