Detailed information of TA system TA233345

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 51040..51698
• Replicon: chromosome
• Accession: NZ_CP091454
• Organism: Acinetobacter baumannii strain AB329

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: LGY76_RS19550
• Protein ID: WP_000312250.1
• Coordinates: 51339..51698 (-)
• Length: 120 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: LGY76_RS19545
• Protein ID: WP_001096429.1
• Coordinates: 51040..51339 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LGY76_RS19505	46064..47344	+	1281	WP_001093570.1	hypothetical protein	-
LGY76_RS19510	47449..47706	+	258	WP_000834290.1	hypothetical protein	-
LGY76_RS19515	47711..48283	+	573	WP_000443897.1	hypothetical protein	-
LGY76_RS19520	48259..48438	+	180	WP_000387630.1	hypothetical protein	-
LGY76_RS19525	48455..49084	+	630	WP_000701003.1	hypothetical protein	-
LGY76_RS19530	49124..49342	+	219	WP_001043201.1	hypothetical protein	-
LGY76_RS19535	49362..49916	+	555	WP_000790084.1	hypothetical protein	-
LGY76_RS19540	49966..50502	+	537	WP_000731978.1	hypothetical protein	-
LGY76_RS19545	51040..51339	-	300	WP_001096429.1	XRE family transcriptional regulator	Antitoxin
LGY76_RS19550	51339..51698	-	360	WP_000312250.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LGY76_RS19555	51899..52465	+	567	WP_000710385.1	hypothetical protein	-
LGY76_RS19565	53952..54650	+	699	WP_000873188.1	hypothetical protein	-
LGY76_RS19570	54789..55172	+	384	WP_000654348.1	hypothetical protein	-
LGY76_RS19575	55239..55997	+	759	WP_001053127.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (14-109)

Antitoxin

• HigA2-like, helix-turn-helix domain (12-88)

Sequences

Toxin

Protein

• Length: 120 a.a.
• Molecular weight: 13751.62 Da
• Isoelectric Point: 4.8212

>T233345 WP_000312250.1 NZ_CP091454:c51698-51339 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Nucleotide

• Length: 360 bp

>T233345 NZ_HG813240:c753925-753617 [Mycobacterium tuberculosis 49-02]
ATGCGGCGCGGTGAATTGTGGTTTGCCGCCACACCTGGTGGTGACAGACCAGTACTTGTCCTTACCAGAGATCCGGTGGC
AGACCGCATCGGCGCGGTCGTTGTGGTGGCCCTAACCCGCACCCGCCGAGGCCTGGTGTCGGAATTGGAGCTCACGGCCG
TCGAAAACCGTGTTCCGAGCGACTGCGTCGTCAACTTCGACAACATTCATACGTTGCCACGCACCGCATTCCGACGCCGC
ATCACCCGGCTGTCCCCGGCCCGCCTGCACGAAGCCTGTCAAACACTCCGGGCGAGCACGGGGTGTTGA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11012.93 Da
• Isoelectric Point: 10.4856

>AT233345 WP_001096429.1 NZ_CP091454:c51339-51040 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Nucleotide

• Length: 300 bp

>AT233345 NZ_HG813240:c754157-753912 [Mycobacterium tuberculosis 49-02]
ATGCTCAGCTTCCGCGCCGACGACCACGACGTCGACCTGGCCGACGCGTGGGCGCGTCGCCTACACATCGGCCGCTCCGA
GCTGCTGCGCGATGCGCTGCGACGTCACTTGGCCGCGCTGGCCGCGGACCAGGATGTCCAGGCCTACACCGAGCGACCGT
TGACGGACGACGAGAACGCACTGGCTGAGATCGCCGACTGGGGGCCGGCGGAGGACTGGGCCGACTGGGCCGATGCGGCG
CGGTGA