Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3887978..3888671 Replicon chromosome
Accession NZ_CP091427
Organism Escherichia coli strain 1000C-3

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag L3Z43_RS18595 Protein ID WP_000415584.1
Coordinates 3888375..3888671 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag L3Z43_RS18590 Protein ID WP_000650107.1
Coordinates 3887978..3888373 (-) Length 132 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L3Z43_RS18580 (3883842) 3883842..3886100 - 2259 WP_032329482.1 DNA topoisomerase IV subunit A -
L3Z43_RS18585 (3886238) 3886238..3887845 - 1608 WP_116290049.1 ABC transporter substrate-binding protein -
L3Z43_RS18590 (3887978) 3887978..3888373 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
L3Z43_RS18595 (3888375) 3888375..3888671 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
L3Z43_RS18600 (3888876) 3888876..3889358 - 483 WP_000183505.1 GyrI-like domain-containing protein -
L3Z43_RS18605 (3889411) 3889411..3889803 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
L3Z43_RS18610 (3889955) 3889955..3890614 + 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
L3Z43_RS18615 (3890611) 3890611..3891960 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
L3Z43_RS18620 (3892006) 3892006..3892338 - 333 WP_000917685.1 DUF2645 family protein -
L3Z43_RS18625 (3892657) 3892657..3893238 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
L3Z43_RS18630 (3893269) 3893269..3893583 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-97)

Antitoxin

(3-47)


Sequences


Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T233324 WP_000415584.1 NZ_CP091427:c3888671-3888375 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T233324 NZ_HG738868:1628899-1629213 [Serratia marcescens SMB2099]
ATGCAATTTACGGTGTATGCGAATAGGGGGAACAGCGCGGTTTATCCCCTGCTGCTTGATGTGACGAGCGATATCATTGG
GCAATTAAATCGTCGAGTTGTGATCCCTTTGTTGCCCGTTGAAAAATACCCGGGGAGTACGCGACCGGAACGCTTGATCC
CGTTGATCAGATTGATTGATGACAACGAGTACGCCGTGATGACATATGAAATGGCCAGCATCCCGGTTCGGGCTTTGGGG
GCCGAGTTTTGTGATGTTTCCCAGTATCGGACCAGGATAAAAGCCGCCATCGACTTTCTTCTTGACGGTATTTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT233324 WP_000650107.1 NZ_CP091427:c3888373-3887978 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT233324 NZ_HG738868:1628660-1628896 [Serratia marcescens SMB2099]
ATGCCAGTAAAACAACGAACGACGCAAAGTGTGACCATGACGGTGGAACGCAGTTTGTTGAGCCGTGCGCGTGAGGCGGG
GATTAATCTCAGCGCGACGCTAACTGCTGCTTTAGATGCTGAGTTACGTCAGCATGAGAGGATAAAATGGCAGGAAGAAA
ACCGAGAGGCGCTTGAAGCGCTTAACCGATTTAATGATGAGCATGGTTGCTTTAGCGACGAATACAGGACGTTTTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 3HI2


Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References