Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 2754831..2755333 | Replicon | chromosome |
| Accession | NZ_CP091427 | ||
| Organism | Escherichia coli strain 1000C-3 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | U9YDH0 |
| Locus tag | L3Z43_RS13310 | Protein ID | WP_000767829.1 |
| Coordinates | 2754831..2755085 (-) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | S1Q063 |
| Locus tag | L3Z43_RS13315 | Protein ID | WP_001259255.1 |
| Coordinates | 2755082..2755333 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L3Z43_RS13280 (2749846) | 2749846..2750073 | - | 228 | WP_000985273.1 | thiosulfate utilization sulfurtransferase TsuB/YeeD | - |
| L3Z43_RS13285 (2750087) | 2750087..2751145 | - | 1059 | WP_000492333.1 | thiosulfate utilization transporter TsuA/YeeE | - |
| L3Z43_RS13290 (2751324) | 2751324..2752682 | - | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
| L3Z43_RS13295 (2752672) | 2752672..2752734 | - | 63 | WP_010723108.1 | membrane protein YoeI | - |
| L3Z43_RS13300 (2752949) | 2752949..2753878 | - | 930 | WP_000803351.1 | LysR substrate-binding domain-containing protein | - |
| L3Z43_RS13305 (2753924) | 2753924..2754748 | - | 825 | WP_000754737.1 | SDR family oxidoreductase | - |
| L3Z43_RS13310 (2754831) | 2754831..2755085 | - | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
| L3Z43_RS13315 (2755082) | 2755082..2755333 | - | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| L3Z43_RS13320 (2755616) | 2755616..2755666 | + | 51 | WP_001364200.1 | his operon leader peptide | - |
| L3Z43_RS13325 (2755812) | 2755812..2756711 | + | 900 | WP_116290091.1 | ATP phosphoribosyltransferase | - |
| L3Z43_RS13330 (2756717) | 2756717..2758021 | + | 1305 | WP_042345632.1 | histidinol dehydrogenase | - |
| L3Z43_RS13335 (2758018) | 2758018..2759088 | + | 1071 | WP_000108991.1 | histidinol-phosphate transaminase | - |
| L3Z43_RS13340 (2759088) | 2759088..2760155 | + | 1068 | WP_000080064.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T233320 WP_000767829.1 NZ_CP091427:c2755085-2754831 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T233320 NZ_HG738868:c63618-63238 [Serratia marcescens SMB2099]
ATGGTGGCTCAACGGGCGTTATTCGACACCAATATCCTGATCGATTATCTCAACGGCATTCCTCAAGCCAAAGACGTTCT
GACCGAATACCACATCAACCCGGCTATTAGCGCCATCACCTGGATGGAAGTGATGGTGGGTGCCAAAAAACAGGGGCCGG
CGCTGGAGCTGAAAACGCGCCAGTTTTTAGGGCAATTCCTGCTGCTGCCTATTACCGATGAAGTTGCCGAACGCGCCGTA
GAATTGCGCCACTCACAGCATGTGAAGCTGCCGGACGCCATTATCTGGGCCACCGCGCAGGTGGGGTTCCGAACGCTCAT
CTCCCGCAACCCCAAAGATTTTGGCACTGACAACGGCGTGTTAATACCTTACCGGCTGTAG
ATGGTGGCTCAACGGGCGTTATTCGACACCAATATCCTGATCGATTATCTCAACGGCATTCCTCAAGCCAAAGACGTTCT
GACCGAATACCACATCAACCCGGCTATTAGCGCCATCACCTGGATGGAAGTGATGGTGGGTGCCAAAAAACAGGGGCCGG
CGCTGGAGCTGAAAACGCGCCAGTTTTTAGGGCAATTCCTGCTGCTGCCTATTACCGATGAAGTTGCCGAACGCGCCGTA
GAATTGCGCCACTCACAGCATGTGAAGCTGCCGGACGCCATTATCTGGGCCACCGCGCAGGTGGGGTTCCGAACGCTCAT
CTCCCGCAACCCCAAAGATTTTGGCACTGACAACGGCGTGTTAATACCTTACCGGCTGTAG
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT233320 WP_001259255.1 NZ_CP091427:c2755333-2755082 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT233320 NZ_HG738868:c63839-63618 [Serratia marcescens SMB2099]
ATGACTCGCATCGTGATCGATTTACCTGAAGAAGACCTGCGGCAGCTCGACAATCTGAAAAATATCCGCCACGTTCCCCG
GGCCGAAATCATCCGTCAGGCCGTCTCCCGTTATCTGACGGAGAACCACGTTGAAGATCCCAGCAATGCTTTCGGGCTCT
GGTCCGGGGCGATGGGCGATGGCGTAGACTACGAAAATCGTCAGCGCGAGGAGTGGGAATAA
ATGACTCGCATCGTGATCGATTTACCTGAAGAAGACCTGCGGCAGCTCGACAATCTGAAAAATATCCGCCACGTTCCCCG
GGCCGAAATCATCCGTCAGGCCGTCTCCCGTTATCTGACGGAGAACCACGTTGAAGATCCCAGCAATGCTTTCGGGCTCT
GGTCCGGGGCGATGGGCGATGGCGTAGACTACGAAAATCGTCAGCGCGAGGAGTGGGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|