Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | txpA-SprF1/- |
| Location | 526820..527127 | Replicon | chromosome |
| Accession | NZ_CP091412 | ||
| Organism | Staphylococcus aureus strain ATR-20003 | ||
Toxin (Protein)
| Gene name | txpA | Uniprot ID | Q2FWU9 |
| Locus tag | L3I92_RS02760 | Protein ID | WP_011447039.1 |
| Coordinates | 526820..526996 (+) | Length | 59 a.a. |
Antitoxin (RNA)
| Gene name | SprF1 | ||
| Locus tag | - | ||
| Coordinates | 526988..527127 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L3I92_RS02740 (522055) | 522055..525840 | + | 3786 | WP_237269210.1 | phage tail spike protein | - |
| L3I92_RS02745 (525830) | 525830..525973 | + | 144 | WP_031783159.1 | hypothetical protein | - |
| L3I92_RS02750 (526029) | 526029..526316 | + | 288 | WP_001040254.1 | hypothetical protein | - |
| L3I92_RS02755 (526374) | 526374..526670 | + | 297 | WP_000539688.1 | DUF2951 domain-containing protein | - |
| L3I92_RS02760 (526820) | 526820..526996 | + | 177 | WP_011447039.1 | type I toxin-antitoxin system toxin PepG1 | Toxin |
| - (526988) | 526988..527127 | - | 140 | NuclAT_0 | - | Antitoxin |
| - (526988) | 526988..527127 | - | 140 | NuclAT_0 | - | Antitoxin |
| - (526988) | 526988..527127 | - | 140 | NuclAT_0 | - | Antitoxin |
| - (526988) | 526988..527127 | - | 140 | NuclAT_0 | - | Antitoxin |
| L3I92_RS02765 (527049) | 527049..527156 | - | 108 | WP_031790389.1 | hypothetical protein | - |
| L3I92_RS02770 (527208) | 527208..527462 | + | 255 | WP_000611512.1 | phage holin | - |
| L3I92_RS02775 (527474) | 527474..528229 | + | 756 | WP_000861038.1 | CHAP domain-containing protein | - |
| L3I92_RS02780 (528420) | 528420..528911 | + | 492 | WP_000919350.1 | staphylokinase | - |
| L3I92_RS02785 (529561) | 529561..529896 | + | 336 | Protein_542 | SH3 domain-containing protein | - |
| L3I92_RS02790 (529991) | 529991..530440 | - | 450 | WP_000727649.1 | chemotaxis-inhibiting protein CHIPS | - |
| L3I92_RS02795 (531124) | 531124..531474 | + | 351 | WP_000702263.1 | complement inhibitor SCIN-A | - |
| L3I92_RS02800 (531527) | 531527..531787 | - | 261 | WP_001791826.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | groEL / hlb / sak / chp / scn | 477058..531474 | 54416 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 59 a.a. Molecular weight: 6849.45 Da Isoelectric Point: 10.6777
>T233280 WP_011447039.1 NZ_CP091412:526820-526996 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK
Download Length: 177 bp
>T233280 NZ_CP091412:526820-526996 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAACAAAAAATAA
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAACAAAAAATAA
Antitoxin
Download Length: 140 bp
>AT233280 NZ_CP091412:c527127-526988 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
