Detailed information of TA system TA233277

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 526820..527158
• Replicon: chromosome
• Accession: NZ_CP091412
• Organism: Staphylococcus aureus strain ATR-20003

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: L3I92_RS02760
• Protein ID: WP_011447039.1
• Coordinates: 526820..526996 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	526984..527158 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L3I92_RS02740	522055..525840	+	3786	WP_237269210.1	phage tail spike protein	-
L3I92_RS02745	525830..525973	+	144	WP_031783159.1	hypothetical protein	-
L3I92_RS02750	526029..526316	+	288	WP_001040254.1	hypothetical protein	-
L3I92_RS02755	526374..526670	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
L3I92_RS02760	526820..526996	+	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	526984..527158	-	175	-	-	Antitoxin
L3I92_RS02770	527208..527462	+	255	WP_000611512.1	phage holin	-
L3I92_RS02775	527474..528229	+	756	WP_000861038.1	CHAP domain-containing protein	-
L3I92_RS02780	528420..528911	+	492	WP_000919350.1	staphylokinase	-
L3I92_RS02785	529561..529896	+	336	Protein_542	SH3 domain-containing protein	-
L3I92_RS02790	529991..530440	-	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
L3I92_RS02795	531124..531474	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
L3I92_RS02800	531527..531787	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL / hlb / sak / chp / scn	477058..531474	54416

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T233277 WP_011447039.1 NZ_CP091412:526820-526996 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T233277 NZ_HG322950:870297-870716 [Pseudomonas knackmussii B13]
ATGATCCTGCTCGACACCAATGTTCTTTCGGAACTGATGCGAGCCAAGCCGGACCCAGCGGTGGTCGCCTGGATCGATGC
GCAGCCTGTGAATGACTTGCACATCAGTGCCATCACCGTGGCAGAGATTCTCTACGGCATTGCCCGGATGCCCGATGGGA
AGCGTAAGCAGGCCCTGCATGACTTGGCCCTCGTGATGTTCGAGGAAGACTTCGCCGGCAACATCCTGCCATTCGATACC
GACGCCGCGGTGCACTACGCCGAGCTGGTAGCGGAGAGTGAGTCCAGGGGAAAAATCGCCGATATGGCGGACGGGCAGAT
TGCGGCAATTGCCCGGCTGCATGGCGCACAAATCGCTACGCGGAATGTCCGCCATTTCGAGCACTTCGGGGTTTCGCTGA
CAGATCCGTGGAAGGACTGA

Antitoxin

Nucleotide

• Length: 175 bp

>AT233277 NZ_CP091412:c527158-526984 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGACTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTGTTG

Structures

Toxin

• PDB: 7NS1

Antitoxin