Detailed information of TA system TA233273

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 69173..69357
• Replicon: chromosome
• Accession: NZ_CP091412
• Organism: Staphylococcus aureus strain ATR-20003

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: L3I92_RS00335
• Protein ID: WP_000482647.1
• Coordinates: 69173..69280 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	69297..69357 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L3I92_RS00310	64537..65010	+	474	WP_000456491.1	GyrI-like domain-containing protein	-
L3I92_RS00315	65133..66344	-	1212	WP_001191975.1	multidrug effflux MFS transporter	-
L3I92_RS00320	66524..67183	-	660	WP_000831298.1	membrane protein	-
L3I92_RS00325	67243..68385	-	1143	WP_001176860.1	glycerate kinase	-
L3I92_RS00330	68653..69039	+	387	WP_000779354.1	flippase GtxA	-
L3I92_RS00335	69173..69280	+	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	69297..69357	-	61	-	-	Antitoxin
L3I92_RS00340	69307..69474	+	168	WP_000301894.1	hypothetical protein	-
L3I92_RS00345	69852..71591	+	1740	WP_001064831.1	ABC transporter ATP-binding protein	-
L3I92_RS00350	71640..73373	+	1734	WP_000488492.1	ABC transporter ATP-binding protein	-
L3I92_RS00355	73604..73771	+	168	WP_031785511.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T233273 WP_000482647.1 NZ_CP091412:69173-69280 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T233273 NZ_HG322949:5592139-5592414 [Janthinobacterium agaricidamnosum NBRC 102515 = DSM 9628]
ATGCTTCCTGTTCAATGGCACCCCAACGCCAGGGCCAAGCTGGCCGCCATCCTCGAGTATATTGCCGAACACAATGACGT
TGCCGCTTCCGCGCTGCAGGCCGACATCGAACGTGCCGCCTCCCGGTTGCAGCAGCACCCCTGCCTGTACCGCCGCGGCC
GGGTCGCCGGCACGCGGGAAATCGTCGTGCATCCTCATTATGTGCTGGTGTACCGCATCCGGCCGAGTGTGATTGAAATC
ATCGCGGTCCTGCACTCGCGCCAGCAGTACCCGTGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT233273 NZ_CP091412:c69357-69297 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin