Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | txpA-SprF1/- |
| Location | 19731..20038 | Replicon | chromosome |
| Accession | NZ_CP091412 | ||
| Organism | Staphylococcus aureus strain ATR-20003 | ||
Toxin (Protein)
| Gene name | txpA | Uniprot ID | Q2FWU9 |
| Locus tag | L3I92_RS00105 | Protein ID | WP_011447039.1 |
| Coordinates | 19731..19907 (+) | Length | 59 a.a. |
Antitoxin (RNA)
| Gene name | SprF1 | ||
| Locus tag | - | ||
| Coordinates | 19899..20038 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L3I92_RS00085 (14966) | 14966..18751 | + | 3786 | WP_237269210.1 | phage tail spike protein | - |
| L3I92_RS00090 (18741) | 18741..18884 | + | 144 | WP_031783159.1 | hypothetical protein | - |
| L3I92_RS00095 (18940) | 18940..19227 | + | 288 | WP_001040254.1 | hypothetical protein | - |
| L3I92_RS00100 (19285) | 19285..19581 | + | 297 | WP_000539688.1 | DUF2951 domain-containing protein | - |
| L3I92_RS00105 (19731) | 19731..19907 | + | 177 | WP_011447039.1 | type I toxin-antitoxin system toxin PepG1 | Toxin |
| - (19899) | 19899..20038 | - | 140 | NuclAT_1 | - | Antitoxin |
| - (19899) | 19899..20038 | - | 140 | NuclAT_1 | - | Antitoxin |
| - (19899) | 19899..20038 | - | 140 | NuclAT_1 | - | Antitoxin |
| - (19899) | 19899..20038 | - | 140 | NuclAT_1 | - | Antitoxin |
| L3I92_RS00110 (19960) | 19960..20067 | - | 108 | WP_031790389.1 | hypothetical protein | - |
| L3I92_RS00115 (20119) | 20119..20373 | + | 255 | WP_000611512.1 | phage holin | - |
| L3I92_RS00120 (20385) | 20385..21140 | + | 756 | WP_237269211.1 | CHAP domain-containing protein | - |
| L3I92_RS00125 (21633) | 21633..22802 | - | 1170 | Protein_24 | AbgT family transporter | - |
| L3I92_RS00130 (23038) | 23038..23856 | + | 819 | WP_000824951.1 | SDR family oxidoreductase | - |
| L3I92_RS00135 (23957) | 23957..24724 | + | 768 | WP_049295992.1 | MBL fold metallo-hydrolase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1..21140 | 21139 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 59 a.a. Molecular weight: 6849.45 Da Isoelectric Point: 10.6777
>T233272 WP_011447039.1 NZ_CP091412:19731-19907 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK
Download Length: 177 bp
>T233272 NZ_HG322949:c1705553-1705245 [Janthinobacterium agaricidamnosum NBRC 102515 = DSM 9628]
ATGACGGTGGCGCTGTGGCGTATCGCGGCCACCACCGCCACTTACGAGGCGAACGACCTGTCAGGTACCGGCGCTAAACA
TACGGGCGGGCGCTGGAATCCGGTCGGCTGGGACGCGAATCCGGCGGGCATGACCAGCGTGCAGGCCGGTGAGGCATGGC
TAAAGGGTAAAGCCTCTGCACTGCTGGTGGTGCCTTCGGTGATCGTGCCGGAGGAATCGAATATCCTGATCAATCCGCTG
CACCCTGATGCGGCGGCCATTACCGCCACGCCTTTGCGCAAGTGGCATCATGACGCGCGCTACTTCTGA
ATGACGGTGGCGCTGTGGCGTATCGCGGCCACCACCGCCACTTACGAGGCGAACGACCTGTCAGGTACCGGCGCTAAACA
TACGGGCGGGCGCTGGAATCCGGTCGGCTGGGACGCGAATCCGGCGGGCATGACCAGCGTGCAGGCCGGTGAGGCATGGC
TAAAGGGTAAAGCCTCTGCACTGCTGGTGGTGCCTTCGGTGATCGTGCCGGAGGAATCGAATATCCTGATCAATCCGCTG
CACCCTGATGCGGCGGCCATTACCGCCACGCCTTTGCGCAAGTGGCATCATGACGCGCGCTACTTCTGA
Antitoxin
Download Length: 140 bp
>AT233272 NZ_CP091412:c20038-19899 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
