Detailed information of TA system TA233272

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 19731..20038
• Replicon: chromosome
• Accession: NZ_CP091412
• Organism: Staphylococcus aureus strain ATR-20003

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: L3I92_RS00105
• Protein ID: WP_011447039.1
• Coordinates: 19731..19907 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	19899..20038 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L3I92_RS00085	14966..18751	+	3786	WP_237269210.1	phage tail spike protein	-
L3I92_RS00090	18741..18884	+	144	WP_031783159.1	hypothetical protein	-
L3I92_RS00095	18940..19227	+	288	WP_001040254.1	hypothetical protein	-
L3I92_RS00100	19285..19581	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
L3I92_RS00105	19731..19907	+	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	19899..20038	-	140	NuclAT_1	-	Antitoxin
-	19899..20038	-	140	NuclAT_1	-	Antitoxin
-	19899..20038	-	140	NuclAT_1	-	Antitoxin
-	19899..20038	-	140	NuclAT_1	-	Antitoxin
L3I92_RS00110	19960..20067	-	108	WP_031790389.1	hypothetical protein	-
L3I92_RS00115	20119..20373	+	255	WP_000611512.1	phage holin	-
L3I92_RS00120	20385..21140	+	756	WP_237269211.1	CHAP domain-containing protein	-
L3I92_RS00125	21633..22802	-	1170	Protein_24	AbgT family transporter	-
L3I92_RS00130	23038..23856	+	819	WP_000824951.1	SDR family oxidoreductase	-
L3I92_RS00135	23957..24724	+	768	WP_049295992.1	MBL fold metallo-hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1..21140	21139

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T233272 WP_011447039.1 NZ_CP091412:19731-19907 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T233272 NZ_HG322949:c1705553-1705245 [Janthinobacterium agaricidamnosum NBRC 102515 = DSM 9628]
ATGACGGTGGCGCTGTGGCGTATCGCGGCCACCACCGCCACTTACGAGGCGAACGACCTGTCAGGTACCGGCGCTAAACA
TACGGGCGGGCGCTGGAATCCGGTCGGCTGGGACGCGAATCCGGCGGGCATGACCAGCGTGCAGGCCGGTGAGGCATGGC
TAAAGGGTAAAGCCTCTGCACTGCTGGTGGTGCCTTCGGTGATCGTGCCGGAGGAATCGAATATCCTGATCAATCCGCTG
CACCCTGATGCGGCGGCCATTACCGCCACGCCTTTGCGCAAGTGGCATCATGACGCGCGCTACTTCTGA

Antitoxin

Nucleotide

• Length: 140 bp

>AT233272 NZ_CP091412:c20038-19899 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin