Detailed information of TA system TA023323

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3641777..3642035
• Replicon: chromosome
• Accession: NC_011740
• Organism: Escherichia fergusonii ATCC 35469

Toxin (Protein)

• Gene name: hokA
• Uniprot ID: -
• Locus tag: EFER_RS17845
• Protein ID: WP_001135723.1
• Coordinates: 3641777..3641929 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokA
Locus tag	-
Coordinates	3641980..3642035 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EFER_RS17820	3637641..3638351	-	711	WP_000190514.1	DUF3053 domain-containing protein	-
EFER_RS17825	3638789..3640159	+	1371	WP_000184983.1	MFS transporter	-
EFER_RS17830	3640409..3640699	+	291	WP_000455800.1	HTH-type transcriptional regulator	-
EFER_RS17835	3640981..3641193	+	213	WP_000014594.1	RNA chaperone/antiterminator CspA	-
EFER_RS17840	3641247..3641618	-	372	WP_001037804.1	membrane protein insertion efficiency factor YidD	-
EFER_RS17845	3641777..3641929	-	153	WP_001135723.1	type I toxin-antitoxin system toxin HokA	Toxin
-	3641980..3642035	+	56	-	-	Antitoxin
EFER_RS17850	3642252..3644321	-	2070	WP_001291786.1	glycine--tRNA ligase subunit beta	-
EFER_RS17855	3644331..3645242	-	912	WP_001168544.1	glycine--tRNA ligase subunit alpha	-
EFER_RS17860	3645338..3645637	-	300	WP_024256552.1	YsaB family lipoprotein	-
EFER_RS17865	3645809..3646804	+	996	WP_015953832.1	acyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5899.14 Da
• Isoelectric Point: 6.9160

>T23323 WP_001135723.1 NC_011740:c3641929-3641777 [Escherichia fergusonii ATCC 35469]
MPQKYGLLSLIVICFTLLFFTWMIRDSLCELHIKQESYELAAFLACKLKE

Nucleotide

• Length: 153 bp

>T23323 NC_011740:c3641929-3641777 [Escherichia fergusonii ATCC 35469]
ATGCCGCAGAAATACGGATTACTTTCGTTAATAGTGATTTGTTTCACGCTTTTATTTTTCACCTGGATGATAAGAGATTC
ACTGTGTGAATTGCATATTAAACAGGAGAGTTATGAGCTGGCGGCGTTTTTAGCCTGCAAATTGAAAGAGTAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT23323 NC_011740:3641980-3642035 [Escherichia fergusonii ATCC 35469]
GTTGAAGCATAGAGGCAGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Structures

Antitoxin