Detailed information of TA system TA023321

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-sokC/Ldr(toxin)
• Location: 3612429..3612648
• Replicon: chromosome
• Accession: NC_011740
• Organism: Escherichia fergusonii ATCC 35469

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: EFER_RS24275
• Protein ID: WP_001295224.1
• Coordinates: 3612429..3612536 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	3612585..3612648 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EFER_RS17675	3607472..3609031	+	1560	WP_001070267.1	cellulose biosynthesis protein BcsE	-
EFER_RS17680	3609028..3609219	+	192	WP_000981122.1	cellulose biosynthesis protein BcsF	-
EFER_RS17685	3609216..3610895	+	1680	WP_000192007.1	cellulose biosynthesis protein BcsG	-
EFER_RS23330	3610982..3611089	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
-	3611147..3611201	+	55	NuclAT_19	-	-
-	3611147..3611201	+	55	NuclAT_19	-	-
-	3611147..3611201	+	55	NuclAT_19	-	-
-	3611147..3611201	+	55	NuclAT_19	-	-
-	3611147..3611201	+	55	NuclAT_21	-	-
-	3611147..3611201	+	55	NuclAT_21	-	-
-	3611147..3611201	+	55	NuclAT_21	-	-
-	3611147..3611201	+	55	NuclAT_21	-	-
-	3611147..3611201	+	55	NuclAT_23	-	-
-	3611147..3611201	+	55	NuclAT_23	-	-
-	3611147..3611201	+	55	NuclAT_23	-	-
-	3611147..3611201	+	55	NuclAT_23	-	-
-	3611147..3611201	+	55	NuclAT_25	-	-
-	3611147..3611201	+	55	NuclAT_25	-	-
-	3611147..3611201	+	55	NuclAT_25	-	-
-	3611147..3611201	+	55	NuclAT_25	-	-
-	3611147..3611203	+	57	NuclAT_12	-	-
-	3611147..3611203	+	57	NuclAT_12	-	-
-	3611147..3611203	+	57	NuclAT_12	-	-
-	3611147..3611203	+	57	NuclAT_12	-	-
-	3611147..3611203	+	57	NuclAT_14	-	-
-	3611147..3611203	+	57	NuclAT_14	-	-
-	3611147..3611203	+	57	NuclAT_14	-	-
-	3611147..3611203	+	57	NuclAT_14	-	-
EFER_RS24260	3611464..3611571	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
EFER_RS24270	3611946..3612053	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
EFER_RS24275	3612429..3612536	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	3612585..3612648	+	64	NuclAT_18	-	Antitoxin
-	3612585..3612648	+	64	NuclAT_18	-	Antitoxin
-	3612585..3612648	+	64	NuclAT_18	-	Antitoxin
-	3612585..3612648	+	64	NuclAT_18	-	Antitoxin
-	3612585..3612648	+	64	NuclAT_20	-	Antitoxin
-	3612585..3612648	+	64	NuclAT_20	-	Antitoxin
-	3612585..3612648	+	64	NuclAT_20	-	Antitoxin
-	3612585..3612648	+	64	NuclAT_20	-	Antitoxin
-	3612585..3612648	+	64	NuclAT_22	-	Antitoxin
-	3612585..3612648	+	64	NuclAT_22	-	Antitoxin
-	3612585..3612648	+	64	NuclAT_22	-	Antitoxin
-	3612585..3612648	+	64	NuclAT_22	-	Antitoxin
-	3612585..3612648	+	64	NuclAT_24	-	Antitoxin
-	3612585..3612648	+	64	NuclAT_24	-	Antitoxin
-	3612585..3612648	+	64	NuclAT_24	-	Antitoxin
-	3612585..3612648	+	64	NuclAT_24	-	Antitoxin
-	3612585..3612650	+	66	NuclAT_11	-	-
-	3612585..3612650	+	66	NuclAT_11	-	-
-	3612585..3612650	+	66	NuclAT_11	-	-
-	3612585..3612650	+	66	NuclAT_11	-	-
-	3612585..3612650	+	66	NuclAT_13	-	-
-	3612585..3612650	+	66	NuclAT_13	-	-
-	3612585..3612650	+	66	NuclAT_13	-	-
-	3612585..3612650	+	66	NuclAT_13	-	-
EFER_RS17705	3612972..3614168	+	1197	WP_001016304.1	methionine gamma-lyase	-
EFER_RS17710	3614418..3615716	+	1299	WP_001152710.1	amino acid permease	-
EFER_RS17715	3615732..3616943	-	1212	WP_024256550.1	sigma 54-interacting transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T23321 WP_001295224.1 NC_011740:c3612536-3612429 [Escherichia fergusonii ATCC 35469]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T23321 NC_011740:c3612536-3612429 [Escherichia fergusonii ATCC 35469]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 64 bp

>AT23321 NC_011740:3612585-3612648 [Escherichia fergusonii ATCC 35469]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin