Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 3862730..3863316 Replicon chromosome
Accession NZ_CP091326
Organism Klebsiella pneumoniae strain hvK2115

Toxin (Protein)


Gene name doc Uniprot ID A0A7Z9B6M3
Locus tag L3Y29_RS18990 Protein ID WP_029884514.1
Coordinates 3862730..3863098 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag L3Y29_RS18995 Protein ID WP_004174006.1
Coordinates 3863095..3863316 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L3Y29_RS18970 (3858233) 3858233..3859303 - 1071 WP_004150074.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -
L3Y29_RS18975 (3859305) 3859305..3860150 - 846 WP_004901101.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
L3Y29_RS18980 (3860147) 3860147..3861034 - 888 WP_004901104.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
L3Y29_RS18985 (3861141) 3861141..3862457 - 1317 WP_029884515.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
L3Y29_RS18990 (3862730) 3862730..3863098 - 369 WP_029884514.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
L3Y29_RS18995 (3863095) 3863095..3863316 - 222 WP_004174006.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
L3Y29_RS19000 (3863480) 3863480..3864193 - 714 WP_029884513.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
L3Y29_RS19005 (3864195) 3864195..3864962 - 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
L3Y29_RS19010 (3864959) 3864959..3866236 - 1278 WP_004174005.1 branched chain amino acid ABC transporter permease LivM -
L3Y29_RS19015 (3866233) 3866233..3867159 - 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 3857496..3866236 8740


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(6-116)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13583.01 Da        Isoelectric Point: 8.6410

>T233153 WP_029884514.1 NZ_CP091326:c3863098-3862730 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRMALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T233153 NZ_CP128545:5193302-5193769 [Pseudomonas monteilii]
ATGAGTGATGCGAGCAGGAAGCCTCTGGTTATTCATGGATGGACTGTAATTGCCCACCCGCTGTTCCTGGCCAAACTGGA
GGCACTCAGCGCTCAAGTGCAGGCTCAGATGCACAAGGACCCAACGGGTTACACGCGCAGAAATGCCTATAAAAGGCTGG
CGGCCATCAAGCGACTGGCCTTCGATGTAATCCCTCAAGACCCGACCAAACCTGAGTACCGGCAGGGGGCCACACTGGGT
GGTGACCACAAGCACTGGTTCAGGGCAAAGTTCTTCCAGCAGTACCGGTTGTTCTTCCGCTATCACACCCCCAGCAGGAT
CATTGTGCTGGCCTGGGTCAATGACGAGTCGAGCAAGCGGGCCTACGAAAGTAGCGACGATGCTTACAAGGTCTTTCAGA
AGATGCTGCATACCGGCCACCCGCCGGACGATTGGGAGCAGCTACTGCGAGAAGCTGCAGCCGAATGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT233153 WP_004174006.1 NZ_CP091326:c3863316-3863095 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT233153 NZ_CP128545:5192979-5193305 [Pseudomonas monteilii]
ATGGCAACCACTCTCGACGTCGAGTCCACACTGACCGATCGCTATCAGACCACTGTTCCCGAAACAGTACGGCGCGCCTT
GGGCTTGAAAAAACGTGACAAGATCCATTACTCGATTCGCCCTGACGGTGAGGTGATACTCACCCGTGCAGAAGCAACCG
AGAGCGATCCAGTACTGGGCAAATTTCTGGATTTCCTGGCACACGATATCGCCACCAACCCTCAACGGCTGCAGGTTGTC
GATGCTGACCTCATCGCGCGTCTCGACAAGCTTGTCGGCGACGCAGAGGTCGACCTGGATCAATCTCTGTCGGCGGATGA
TGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z9B6M3

Antitoxin

Source ID Structure
AlphaFold DB A0A5E5YJY7

References