Detailed information of TA system TA023315

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symE-timR/SymE(toxin)
• Location: 3159712..3160124
• Replicon: chromosome
• Accession: NC_011740
• Organism: Escherichia fergusonii ATCC 35469

Toxin (Protein)

• Gene name: symE
• Uniprot ID: -
• Locus tag: EFER_RS15535
• Protein ID: WP_000132635.1
• Coordinates: 3159783..3160124 (+)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	timR
Locus tag	-
Coordinates	3159712..3159788 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EFER_RS15525	3156461..3158050	+	1590	WP_001063202.1	type I restriction-modification system methyltransferase	-
EFER_RS15530	3158047..3159555	+	1509	WP_001272443.1	restriction endonuclease subunit S	-
-	3159712..3159788	-	77	NuclAT_15	-	Antitoxin
-	3159712..3159788	-	77	NuclAT_15	-	Antitoxin
-	3159712..3159788	-	77	NuclAT_15	-	Antitoxin
-	3159712..3159788	-	77	NuclAT_15	-	Antitoxin
-	3159712..3159788	-	77	NuclAT_16	-	Antitoxin
-	3159712..3159788	-	77	NuclAT_16	-	Antitoxin
-	3159712..3159788	-	77	NuclAT_16	-	Antitoxin
-	3159712..3159788	-	77	NuclAT_16	-	Antitoxin
EFER_RS15535	3159783..3160124	+	342	WP_000132635.1	endoribonuclease SymE	Toxin
EFER_RS15540	3160286..3161665	+	1380	WP_015953743.1	5-methylcytosine-specific restriction endonuclease subunit McrB	-
EFER_RS15545	3161665..3162711	+	1047	WP_015953744.1	5-methylcytosine-specific restriction endonuclease system specificity protein McrC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12310.12 Da
• Isoelectric Point: 7.8218

>T23315 WP_000132635.1 NC_011740:3159783-3160124 [Escherichia fergusonii ATCC 35469]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEVAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQDFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T23315 NC_011740:3159783-3160124 [Escherichia fergusonii ATCC 35469]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGTCGCCGGTTTTGCCA
CCGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACTGCCCAACCACCCGCCGCCGAAGAGAGCGAA
CTGATGCAGTCACTGCGCCAGGTATGCAAATTGTCGGCGCGTAAACAAAAGCAGGTGCAGGATTTTATTGGGGTAATTGC
GGGTAAACAGAAAGTCGCGTAA

Antitoxin

Nucleotide

• Length: 77 bp

>AT23315 NC_011740:c3159788-3159712 [Escherichia fergusonii ATCC 35469]
AGTCATAACTGCTATTCTCCTGAAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Antitoxin