Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2834338..2835038 Replicon chromosome
Accession NZ_CP091308
Organism Burkholderia pyrrocinia strain LWK2

Toxin (Protein)


Gene name mqsR Uniprot ID A0A0G3X296
Locus tag L2Y90_RS30280 Protein ID WP_047903229.1
Coordinates 2834338..2834634 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID A0A0G3X002
Locus tag L2Y90_RS30285 Protein ID WP_047903228.1
Coordinates 2834637..2835038 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2Y90_RS30265 (L2Y90_30210) 2830874..2832424 + 1551 WP_258283809.1 sensor domain-containing diguanylate cyclase -
L2Y90_RS30270 (L2Y90_30215) 2832682..2832954 + 273 WP_258283810.1 hypothetical protein -
L2Y90_RS30275 (L2Y90_30220) 2833195..2834229 + 1035 WP_258283811.1 succinylglutamate desuccinylase/aspartoacylase family protein -
L2Y90_RS30280 (L2Y90_30225) 2834338..2834634 + 297 WP_047903229.1 type II toxin-antitoxin system MqsR family toxin Toxin
L2Y90_RS30285 (L2Y90_30230) 2834637..2835038 + 402 WP_047903228.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
L2Y90_RS30290 (L2Y90_30235) 2835354..2835914 + 561 WP_258283812.1 GNAT family N-acetyltransferase -
L2Y90_RS30295 (L2Y90_30240) 2835968..2836909 + 942 WP_258283813.1 ABC transporter substrate-binding protein -
L2Y90_RS30300 (L2Y90_30245) 2836962..2838011 + 1050 WP_258283814.1 LLM class flavin-dependent oxidoreductase -
L2Y90_RS30305 (L2Y90_30250) 2838019..2839371 + 1353 WP_258283815.1 LLM class flavin-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-97)

Antitoxin

Zinc finger, MqsA-type

(3-46)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11247.15 Da        Isoelectric Point: 8.9573

>T233116 WP_047903229.1 NZ_CP091308:2834338-2834634 [Burkholderia pyrrocinia]
MEKRRPHCKLPLVKALVESGKVRLTTSAVLGARQLGFTEREALDVVMSLTDLDFHKSMTTYADHTIWQDVYRPLTVRGDV
YLKLTVIDEVLIVSFKER

Download         Length: 297 bp

>T233116 NZ_CP128531:1307502-1307678 [Mannheimia haemolytica]
GTGAAGCAAAGCGAATTCCTAAGGTGGCTAAAGGCTAATGGGGTAGAGGTTGAAAATGGATCAAAGCATTTGAAACTCTA
CTACAAGGGCAAAAGAAGCCACCTCCCCAAACACCCAAGCCAAGAGTTAAAAACAGGCTTAGTGGAAGGGGTTAAAAAGC
AACTAGGCTTAAAATAA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14619.91 Da        Isoelectric Point: 8.8304

>AT233116 WP_047903228.1 NZ_CP091308:2834637-2835038 [Burkholderia pyrrocinia]
MKCPACGAAKLVRDTRDIPYTYKGRSTVVRDITGDFCPACGESVLDLDEATRLGEAIAEFNKQVNATIVDPKYIAKVRKK
LRLDQREAAELFGGGVNAFSRYETGKTNPPLALVKLLKILDRHPDLLAEVRAA

Download         Length: 402 bp

>AT233116 NZ_CP128531:1307734-1308150 [Mannheimia haemolytica]
ATGTTTTATCCAGCGTTATTTACCCCCGCTGAAGAAGGGGGCTTTGTAGTGACATTTCCTGATTTGCCAGAAGCTATCAC
CCAAGGCGATACATTTGAAGAAGCAATGGAAATGGCAGAAGACGTGCTACTATCTTGTGTTGAAATTTATTTCGATGAAG
ATAGACGCTTTCCGCTCACTCGCCCAGTAAATACCGACGAAGTGCCTGTGTTTATGCCAGAGAGCATCTACGCAAAAGTG
CTTTTGCATAATACAATGCAAGAACAAGCGGTAAGCAAGGCAGAAATTGCCCGATTAACTAATATCCGTCCGCCAGAAGT
ACAGCGAATTTTAGCCCCTCGCCATATTACAAAAATCGACACTATTGGTCGTATTTTGGCTAGCTTAGGAAAGCCCCTAC
AACTATCCCTAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0G3X296

Antitoxin

Source ID Structure
AlphaFold DB A0A0G3X002

References