Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1937095..1937688 Replicon chromosome
Accession NZ_CP091308
Organism Burkholderia pyrrocinia strain LWK2

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag L2Y90_RS26310 Protein ID WP_258283240.1
Coordinates 1937410..1937688 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag L2Y90_RS26305 Protein ID WP_034185116.1
Coordinates 1937095..1937397 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2Y90_RS26280 (L2Y90_26225) 1932246..1933517 + 1272 WP_152855722.1 anthranilate 1,2-dioxygenase large subunit AndAc -
L2Y90_RS26285 (L2Y90_26230) 1933532..1934008 + 477 WP_131948025.1 anthranilate 1,2-dioxygenase small subunit AndAd -
L2Y90_RS26290 (L2Y90_26235) 1934026..1934352 + 327 WP_048022186.1 anthranilate 1,2-dioxygenase ferredoxin subunit AndAb -
L2Y90_RS26295 (L2Y90_26240) 1934342..1935562 + 1221 WP_258283238.1 anthranilate 1,2-dioxygenase system ferredoxin--NAD(+) reductase -
L2Y90_RS26300 (L2Y90_26245) 1935775..1937061 + 1287 WP_258283239.1 DUF445 domain-containing protein -
L2Y90_RS26305 (L2Y90_26250) 1937095..1937397 - 303 WP_034185116.1 HigA family addiction module antitoxin Antitoxin
L2Y90_RS26310 (L2Y90_26255) 1937410..1937688 - 279 WP_258283240.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L2Y90_RS26315 (L2Y90_26260) 1938054..1938353 - 300 WP_034185118.1 putative addiction module antidote protein -
L2Y90_RS26320 (L2Y90_26265) 1938357..1938674 - 318 WP_258283241.1 type II toxin-antitoxin system RelE/ParE family toxin -
L2Y90_RS26325 (L2Y90_26270) 1939023..1940663 + 1641 WP_152855717.1 acetolactate synthase large subunit -
L2Y90_RS26330 (L2Y90_26275) 1940693..1942126 + 1434 WP_258283242.1 aldehyde dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10655.12 Da        Isoelectric Point: 8.5478

>T233113 WP_258283240.1 NZ_CP091308:c1937688-1937410 [Burkholderia pyrrocinia]
MIRSFRCKDTQLLFAGASPRRFRTIETVASRKLQMVAAAKELRDLRAPPGNRLEALQGDREGQHGIRINEQWRICFEWSD
DGPTQVEIVDYH

Download         Length: 279 bp

>T233113 NZ_CP128531:c194550-194218 [Mannheimia haemolytica]
ATGAAACGTGGCGATATTTACTGGCTCGATCTTGATCCAACCTTAGGACACGAACAATCAGGCTTCCGCCCCGTTGTAAT
TGTTTCCGCAACTGCATTTAATCTAGCCAGTAAACTGCCTGTGGTTGTGCCGATTACTAACGGTGGAGCTTTTGCTGAAA
GACTGGGCTTTGCCGTTTCATTAAAAGATGCCGGCTTAAAAACAACAGGGATTATTCGATGCGATCAACCTCGCACAGTC
GATATTGCACAACGCCATGGAAAATTTATCGAAGCCTTACCCGAAAGCCTACTTGATGAAATTATGGCAAGGGTTTCAGT
GATTTTTGAGTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11570.36 Da        Isoelectric Point: 8.5562

>AT233113 WP_034185116.1 NZ_CP091308:c1937397-1937095 [Burkholderia pyrrocinia]
MLKNGMRPIHPGEILREEFLVPLEMSVNALALALNVPATRLHEIVKERRGITADTAYRLARYFDTSPEFWLNLQAAYDLK
TLPTRSEIDRKVEPRERTHA

Download         Length: 303 bp

>AT233113 NZ_CP128531:c194807-194547 [Mannheimia haemolytica]
ATGCCAACAATCGCATTACGTCAGGTCGGTGGCTCGGTTGCAATGGTGATTCCGCCTGCTTTTTTAGAGGCACTCAAGCT
CTCCGTCGGTAGCAAAGTGGATTTGTCTTTAAACGACAACCAACTCGTGATTAATCCTGCCCGCCCAAAAGTGAAATACA
GCTTAGAGGAATTATTAAGACAATCCGATTTTGAGGCAGCAAGGAATGAAGAAAGCCAATCATGGTTATCCGAGCCGGCA
ATAGGAAAAGAAATTTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References