Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 1398961..1399576 Replicon chromosome
Accession NZ_CP091308
Organism Burkholderia pyrrocinia strain LWK2

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag L2Y90_RS23850 Protein ID WP_258284896.1
Coordinates 1399235..1399576 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag L2Y90_RS23845 Protein ID WP_258284895.1
Coordinates 1398961..1399248 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2Y90_RS23815 (L2Y90_23765) 1394437..1395216 - 780 WP_258284890.1 5'/3'-nucleotidase SurE -
L2Y90_RS23820 (L2Y90_23770) 1395523..1395831 - 309 WP_027789978.1 AzlD family protein -
L2Y90_RS23825 (L2Y90_23775) 1395824..1396558 - 735 WP_258284891.1 AzlC family ABC transporter permease -
L2Y90_RS23830 (L2Y90_23780) 1396684..1397142 + 459 WP_258284892.1 Lrp/AsnC family transcriptional regulator -
L2Y90_RS23835 (L2Y90_23785) 1397363..1397932 + 570 WP_258284893.1 hypothetical protein -
L2Y90_RS23840 (L2Y90_23790) 1398196..1398885 + 690 WP_258284894.1 YebB family permuted papain-like enzyme -
L2Y90_RS23845 (L2Y90_23795) 1398961..1399248 - 288 WP_258284895.1 helix-turn-helix transcriptional regulator Antitoxin
L2Y90_RS23850 (L2Y90_23800) 1399235..1399576 - 342 WP_258284896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L2Y90_RS23855 (L2Y90_23805) 1399792..1400424 - 633 WP_258284897.1 LysE family translocator -
L2Y90_RS23860 (L2Y90_23810) 1400733..1402490 + 1758 WP_258284898.1 ShlB/FhaC/HecB family hemolysin secretion/activation protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(21-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-90)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13112.34 Da        Isoelectric Point: 10.3852

>T233112 WP_258284896.1 NZ_CP091308:c1399576-1399235 [Burkholderia pyrrocinia]
MRTVADEIHFFSEQVEAGVFALPKTLTARFFALADRMERYGPNLGEPHTRPMGDGLYEMRLKGLEGIARVFYCAVVNRRI
VMLHCFVKKTRKTPQKELETARRRLKEIRDGNL

Download         Length: 342 bp

>T233112 NZ_CP128531:c22752-22324 [Mannheimia haemolytica]
ATGTATCGCTACCTTTTTGATACCAATATAGTTTCCGAGCTTTATAAGTTAAGAAATGACAAGATGGATGTCAATGTTCG
CCAGTGGCTGAGAGGGGTTAATCCTAGCCAGACCAATATCAGCTGTATTACGTTATCTGAAATCAAAACAGGTATTTTGC
TGAAAGCCCGCAAAGACAAAGAACAATCAGACCGATTAAATGATTGGTTTGAAAATAATGTATTAAAGGCTTATCAAACA
AAAGCGTTTGTGGTGAATAACGACATTGCTCTATTGGCATCAGAGTACCATATTCCCAATAAAATGGATTTAAATGATGC
TTATATTGCGGCAACCGCCAAATACCACAATCTGATTTTAGTCACCCGCAACACCAAAGATTTTATCCGTTGTGATGTGC
GTTTATTTAACCCATTTGAAACCGCATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10378.00 Da        Isoelectric Point: 10.2764

>AT233112 WP_258284895.1 NZ_CP091308:c1399248-1398961 [Burkholderia pyrrocinia]
MATYKALRERALADPTVRAEYERLNREEFALLDAMLAARRAAGLSQADVAERMGTKAPAVTRLERALATGQHSPSIETLR
KYAAACGKKLVISFA

Download         Length: 288 bp

>AT233112 NZ_CP128531:c23039-22752 [Mannheimia haemolytica]
ATGGCAATAACCATTACTTCCAGAGAATTTAATCAAAATGCCAGCAAAGTGTTAAAAATGGCAGAAAAAGAGCCGGTTTT
TATTACCAAATGGGGCAAAATCGTCAATGTGGTGTCTAGTTATATGGATTATCAGCAGAAAAAGCCTAGCGAGCCAAGCT
TTGAAGAGCTATTCGCCTCTTCCGAAAATGAGGATGTGAGCGATGAATTTTGGCAAGAGTTTGAACAAACATTGGTTGAA
ATCCGCAAAAGCAATAAACCAAGACCTGTTGATTTTGGAGATGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References