Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2127032..2127534 Replicon chromosome
Accession NC_011740
Organism Escherichia fergusonii ATCC 35469

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag EFER_RS10555 Protein ID WP_000767829.1
Coordinates 2127032..2127286 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag EFER_RS10560 Protein ID WP_001259255.1
Coordinates 2127283..2127534 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EFER_RS10530 2122049..2122276 - 228 WP_000985273.1 sulfurtransferase TusA family protein -
EFER_RS10535 2122290..2123348 - 1059 WP_000492054.1 transport protein YeeE -
EFER_RS10540 2123526..2124884 - 1359 WP_000019201.1 putrescine/proton symporter PlaP -
EFER_RS24095 2124874..2124936 - 63 WP_010723108.1 membrane protein YoeI -
EFER_RS10545 2125150..2126079 - 930 WP_000803362.1 LysR family transcriptional regulator -
EFER_RS10550 2126125..2126949 - 825 WP_000754724.1 SDR family oxidoreductase -
EFER_RS10555 2127032..2127286 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
EFER_RS10560 2127283..2127534 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
EFER_RS23020 2127818..2127868 + 51 WP_001364200.1 his operon leader peptide -
EFER_RS10565 2128014..2128913 + 900 WP_000131779.1 ATP phosphoribosyltransferase -
EFER_RS10570 2128919..2130223 + 1305 WP_015953522.1 histidinol dehydrogenase -
EFER_RS10575 2130220..2131290 + 1071 WP_000108922.1 histidinol-phosphate transaminase -
EFER_RS10580 2131290..2132357 + 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T23310 WP_000767829.1 NC_011740:c2127286-2127032 [Escherichia fergusonii ATCC 35469]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T23310 NC_011740:c2127286-2127032 [Escherichia fergusonii ATCC 35469]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACTCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT23310 WP_001259255.1 NC_011740:c2127534-2127283 [Escherichia fergusonii ATCC 35469]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT23310 NC_011740:c2127534-2127283 [Escherichia fergusonii ATCC 35469]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAACGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCCCTGGAAGAGACGGCTTATC
TATTGCGTTCCCCCGCTAATGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References