Detailed information of TA system TA233091

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 2686609..2687211
• Replicon: chromosome
• Accession: NZ_CP091300
• Organism: Salmonella enterica subsp. enterica serovar Bovismorbificans strain SB699

Toxin (Protein)

• Gene name: higB
• Uniprot ID: M7S4R6
• Locus tag: L1971_RS13800
• Protein ID: WP_001159635.1
• Coordinates: 2686900..2687211 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: L1971_RS13795
• Protein ID: WP_000362050.1
• Coordinates: 2686609..2686899 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L1971_RS13780 (2684102)	2684102..2685004	+	903	WP_000331364.1	formate dehydrogenase subunit beta	-
L1971_RS13785 (2685001)	2685001..2685636	+	636	WP_000829028.1	formate dehydrogenase cytochrome b556 subunit	-
L1971_RS13790 (2685633)	2685633..2686562	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
L1971_RS13795 (2686609)	2686609..2686899	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
L1971_RS13800 (2686900)	2686900..2687211	-	312	WP_001159635.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
L1971_RS13805 (2687429)	2687429..2688358	+	930	WP_024798833.1	alpha/beta hydrolase	-
L1971_RS13810 (2688444)	2688444..2688755	+	312	WP_024792370.1	type II toxin-antitoxin system HigB family toxin	-
L1971_RS13815 (2688752)	2688752..2689198	+	447	WP_237123685.1	type II toxin-antitoxin system HigA family antitoxin	-
L1971_RS13820 (2689213)	2689213..2690154	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
L1971_RS13825 (2690199)	2690199..2690636	-	438	WP_000560974.1	D-aminoacyl-tRNA deacylase	-
L1971_RS13830 (2690633)	2690633..2691505	-	873	WP_000921423.1	virulence factor BrkB family protein	-
L1971_RS13835 (2691499)	2691499..2692098	-	600	WP_000965698.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12340.30 Da
• Isoelectric Point: 9.4460

>T233091 WP_001159635.1 NZ_CP091300:c2687211-2686900 [Salmonella enterica subsp. enterica serovar Bovismorbificans]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T233091 NZ_CP128528:1192971-1193147 [Mannheimia haemolytica]
GTGAAGCAAAGCGAATTCCTAAGGTGGCTAAAGGCTAATGGGGTAGAGGTTGAAAATGGATCAAAGCATTTGAAACTCTA
CTACAAGGGCAAAAGAAGCCACCTCCCCAAACACCCAAGCCAAGAGTTAAAAACAGGCTTAGTGGAAGGGGTTAAAAAGC
AACTAGGCTTAAAATAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT233091 WP_000362050.1 NZ_CP091300:c2686899-2686609 [Salmonella enterica subsp. enterica serovar Bovismorbificans]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT233091 NZ_CP128528:1193203-1193619 [Mannheimia haemolytica]
ATGTTTTATCCAGCGTTATTTACCCCCGCTGAAGAAGGGGGCTTTGTAGTGACATTTCCTGATTTGCCAGAAGCTATCAC
CCAAGGCGATACATTTGAAGAAGCAATGGAAATGGCAGAAGACGTGCTACTATCTTGTGTTGAAATTTATTTCGATGAAG
ATAGACGCTTTCCGCTCACTCGCCCAGTAAATACCGACGAAGTGCCTGTGTTTATGCCAGAGAGCATCTACGCAAAAGTG
CTTTTGCATAATACAATGCAAGAACAAGCGGTAAGCAAGGCAGAAATTGCCCGATTAACTAATATCCGTCCGCCAGAAGT
ACAGCGAATTTTAGCCCCTCGCCATATTACAAAAATCGACACTATTGGTCGTATTTTGGCTAGCTTAGGAAAGCCCCTAC
AACTATCCCTAGGATAA

Structures

Toxin

• AlphaFold DB: A0A3V2JK97