Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1529947..1530509 Replicon chromosome
Accession NC_011740
Organism Escherichia fergusonii ATCC 35469

Toxin (Protein)


Gene name higB Uniprot ID L4J948
Locus tag EFER_RS07550 Protein ID WP_000605676.1
Coordinates 1530231..1530509 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag EFER_RS07545 Protein ID WP_000781370.1
Coordinates 1529947..1530231 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EFER_RS07530 1525306..1528353 + 3048 WP_015953395.1 formate dehydrogenase-N subunit alpha -
EFER_RS07535 1528366..1529250 + 885 WP_001240580.1 formate dehydrogenase N subunit beta -
EFER_RS07540 1529243..1529896 + 654 WP_000045645.1 formate dehydrogenase-N subunit gamma -
EFER_RS07545 1529947..1530231 - 285 WP_000781370.1 HigA family addiction module antidote protein Antitoxin
EFER_RS07550 1530231..1530509 - 279 WP_000605676.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EFER_RS07555 1530695..1531705 - 1011 WP_000642397.1 alcohol dehydrogenase AdhP -
EFER_RS07560 1531839..1533536 - 1698 WP_000433464.1 malate dehydrogenase -
EFER_RS07565 1533693..1533830 - 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
EFER_RS07570 1533932..1534147 - 216 WP_000495766.1 biofilm-dependent modulation protein -
EFER_RS07575 1534490..1534921 + 432 WP_000152299.1 peroxiredoxin OsmC -
EFER_RS24060 1534982..1535122 + 141 WP_109043809.1 omptin family outer membrane protease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10521.10 Da        Isoelectric Point: 7.3562

>T23309 WP_000605676.1 NC_011740:c1530509-1530231 [Escherichia fergusonii ATCC 35469]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASCLADIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

>T23309 NC_011740:c1530509-1530231 [Escherichia fergusonii ATCC 35469]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCAAGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ACCCGTTAAGCGGCGATCGTGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGGATAACGTTTGAGTTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT23309 WP_000781370.1 NC_011740:c1530231-1529947 [Escherichia fergusonii ATCC 35469]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp

>AT23309 NC_011740:c1530231-1529947 [Escherichia fergusonii ATCC 35469]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAGCTGAACGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGATTGCTGACCGGAAAAGCCGCGTTGACGCCAGAAATGGCGA
TTAAACTTTCTGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTACAAAACGCCTGGAGTCTGGCAGAGGCAGAA
AAAACGGTAGATGTGTCGCGACTACGCCGTCTGGTTACGCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829G6T1

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References