Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1200218..1200740 Replicon chromosome
Accession NZ_CP091281
Organism Macrococcus canis strain B8

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag L2Z53_RS06125 Protein ID WP_236365520.1
Coordinates 1200218..1200490 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag L2Z53_RS06130 Protein ID WP_086042496.1
Coordinates 1200483..1200740 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2Z53_RS06080 (L2Z53_06080) 1195708..1195896 - 189 WP_086042483.1 2-hydroxymuconate tautomerase -
L2Z53_RS06085 (L2Z53_06085) 1195945..1196949 - 1005 WP_236365517.1 cation diffusion facilitator family transporter -
L2Z53_RS06090 (L2Z53_06090) 1197087..1197557 + 471 WP_086042485.1 GNAT family N-acetyltransferase -
L2Z53_RS06095 (L2Z53_06095) 1197664..1198050 + 387 WP_086042486.1 sporulation protein -
L2Z53_RS06100 (L2Z53_06100) 1198113..1198628 - 516 WP_086042487.1 DUF402 domain-containing protein -
L2Z53_RS06105 (L2Z53_06105) 1198721..1199179 + 459 WP_086042488.1 NUDIX domain-containing protein -
L2Z53_RS06110 (L2Z53_06110) 1199275..1199526 + 252 WP_086042489.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
L2Z53_RS06115 (L2Z53_06115) 1199526..1199786 + 261 WP_236365518.1 Txe/YoeB family addiction module toxin -
L2Z53_RS06120 (L2Z53_06120) 1199779..1200195 + 417 WP_236365519.1 hypothetical protein -
L2Z53_RS06125 (L2Z53_06125) 1200218..1200490 - 273 WP_236365520.1 Txe/YoeB family addiction module toxin Toxin
L2Z53_RS06130 (L2Z53_06130) 1200483..1200740 - 258 WP_086042496.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
L2Z53_RS06135 (L2Z53_06135) 1201030..1201254 + 225 WP_236365521.1 DUF6290 family protein -
L2Z53_RS06140 (L2Z53_06140) 1201251..1201517 + 267 WP_261785718.1 type II toxin-antitoxin system RelE/ParE family toxin -
L2Z53_RS06145 (L2Z53_06145) 1201628..1201996 + 369 WP_236365523.1 GntR family transcriptional regulator -
L2Z53_RS06150 (L2Z53_06150) 1201996..1203096 + 1101 WP_236365524.1 DUF1648 domain-containing protein -
L2Z53_RS06155 (L2Z53_06155) 1203539..1204801 + 1263 WP_236366941.1 Y-family DNA polymerase -
L2Z53_RS06160 (L2Z53_06160) 1204954..1205142 + 189 WP_236365525.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(10-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10694.50 Da        Isoelectric Point: 9.8923

>T233068 WP_236365520.1 NZ_CP091281:c1200490-1200218 [Macrococcus canis]
MPKKKILFYSSGFEDYTYWQTNDKTVLKKIDKLIKSIMIDGANKGIGKPEKLLGNYTGCYSRRITHEHRLVYKIEDDSIC
ILQCRFHYKR

Download         Length: 273 bp

>T233068 NZ_CP128525:c1995784-1995488 [Mannheimia haemolytica]
ATGTATATAGATTTGCAATATGCTGTGCCGTTATTGTTTGAATACGACCCGAACAAAAGCCAAATTAATTTAGCCAAATA
TGGTATTGATTTTGAACAGGCAAAGTTGCTTTGGGAAGATGAACGAAAAGTTGTACTGGAGGCTTGCATTGAACCCGAAT
TACGCTATTTCCTGATTGGCAAGATTTATGATAAATATTGGACAGCGTTTTTTACACCAAGAAATGATGTTATTCGTTTA
ATTTCAGTTAGACGTTCCCGTAAAAAAGAGATCTCATACTATGAGAAATACCATTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9697.75 Da        Isoelectric Point: 4.1540

>AT233068 WP_086042496.1 NZ_CP091281:c1200740-1200483 [Macrococcus canis]
MKVTTYSNARSNFRKIIDIVNEDCEPYTITTNTHNAVILSEQDYNSMIETLYLQSTPANAERLQKAIDESTDKNNLLQVE
IDLDA

Download         Length: 258 bp

>AT233068 NZ_CP128525:c1995504-1995262 [Mannheimia haemolytica]
ATGAGAAATACCATTAGTGCCGAAGAATTAGAACGTATCTTCGATGAAGGCAAAGAAGATATTTTACAATACTGCGATCT
TTCTACCGCTCATCGCCCGGGGCAAATGAAAAGGGTGAATGTTGATTTCCCAAATTGGATGGTAGAAGCGTTAGATAAGC
AAGCCAGACATTTAGGTGTGCCTCGCCAAGCCTTGATTAAAATGTGGATTGCGGAAAAATTACCGGTTCAATCACCTAGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References