Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1360357..1360868 Replicon chromosome
Accession NZ_CP091244
Organism Thiothrix winogradskyi strain CT3

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag L2Y54_RS06910 Protein ID WP_236501082.1
Coordinates 1360614..1360868 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag L2Y54_RS06905 Protein ID WP_236501081.1
Coordinates 1360357..1360614 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2Y54_RS06870 (L2Y54_06870) 1355507..1355998 - 492 WP_236501074.1 hypothetical protein -
L2Y54_RS06875 (L2Y54_06875) 1356072..1356566 - 495 WP_236501075.1 thiol peroxidase -
L2Y54_RS06880 (L2Y54_06880) 1356603..1357874 - 1272 WP_236501076.1 O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase -
L2Y54_RS06885 (L2Y54_06885) 1357946..1358758 + 813 WP_236501077.1 bifunctional DNA-formamidopyrimidine glycosylase/DNA-(apurinic or apyrimidinic site) lyase -
L2Y54_RS06890 (L2Y54_06890) 1358822..1359016 - 195 WP_236501078.1 hypothetical protein -
L2Y54_RS06895 (L2Y54_06895) 1359107..1360075 + 969 WP_236501080.1 tRNA dihydrouridine(20/20a) synthase DusA -
L2Y54_RS06905 (L2Y54_06905) 1360357..1360614 + 258 WP_236501081.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
L2Y54_RS06910 (L2Y54_06910) 1360614..1360868 + 255 WP_236501082.1 Txe/YoeB family addiction module toxin Toxin
L2Y54_RS06915 (L2Y54_06915) 1360879..1361235 - 357 WP_236501083.1 hypothetical protein -
L2Y54_RS06920 (L2Y54_06920) 1361247..1361624 - 378 WP_236501084.1 P-II family nitrogen regulator -
L2Y54_RS06925 (L2Y54_06925) 1361621..1363396 - 1776 WP_236501085.1 DUF1538 domain-containing protein -
L2Y54_RS06930 (L2Y54_06930) 1363491..1364114 - 624 WP_236501086.1 LysE family translocator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10404.86 Da        Isoelectric Point: 7.9170

>T233063 WP_236501082.1 NZ_CP091244:1360614-1360868 [Thiothrix winogradskyi]
MLLCWADDAWDDYLHWQQTDRKILKRVNDLIKDMKRNPFEGVGKPEPLKHQWAGYWSRRITEEHRIVYKVESDHLYIAQC
RYHY

Download         Length: 255 bp

>T233063 NZ_CP128525:296347-296616 [Mannheimia haemolytica]
ATGCGAGAGATTGAGTATAGTAATGCTTTTAAACGTGACTATAAAAAATGTGCGGTTGAGTCTTTATCCTCTTCATTAAT
TGAGGCGTTGTATTTTCTGATTAATGACAAGCCATTACCTGAGAAATACTGCGATCACGCTTTAACCGGCGAATGGAAAG
GCTTTAGGGATTGCCATATCCAACCTGATTTGGTTCTTATCTATCGAAAAGTGGAAGATGATAAGCTAGAGCTGCTGCGA
ATTGGCAGCCACTCTCATTTATTTGGCTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9241.41 Da        Isoelectric Point: 5.0790

>AT233063 WP_236501081.1 NZ_CP091244:1360357-1360614 [Thiothrix winogradskyi]
MEAISYSAFRKGLSNALDKVEQDRVPLLITRQNGTAAVLISLDEYNAYAETAHLAASPKNAERLNRAIAQLEAGRGVVRD
IVEGE

Download         Length: 258 bp

>AT233063 NZ_CP128525:296094-296360 [Mannheimia haemolytica]
ATGGCAAATAGTGCATTAGTAAGCGTAAGAATCAGCCCTGAAATTAAAGAGCAAGCAAGTGAGGTGTTAGCCGGTATCGG
CTTGACTGTCTCTGATGTGATGCGAATGACATTAGCGAAAATCGCAACAGAAAAACGTTTTCAGTTTGATTATCAGCCTA
ATTTTGAGACAGCAGAAGTATTAAGGGCTGTTAAGAATGGCGAGGAAAAGCTACATTCAGCAAATAGTATTGCGGATTTA
ATGGAGCAACTCAATGCGAGAGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References