Detailed information of TA system TA233039

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-RNAII/-
• Location: 2727136..2727387
• Replicon: chromosome
• Accession: NZ_CP091240
• Organism: Enterococcus faecalis strain 249

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: S4BWW4
• Locus tag: LQ065_RS13090
• Protein ID: WP_002404776.1
• Coordinates: 2727136..2727258 (+)
• Length: 41 a.a.

Antitoxin (RNA)

Gene name	RNAII
Locus tag	-
Coordinates	2727324..2727387 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LQ065_RS13075 (2722767)	2722767..2723399	-	633	WP_002358972.1	RloB family protein	-
LQ065_RS13080 (2723408)	2723408..2724703	-	1296	WP_002396787.1	ATP-binding protein	-
LQ065_RS13085 (2725165)	2725165..2726781	+	1617	WP_002358967.1	phosphatase PAP2/LCP family protein	-
LQ065_RS13090 (2727136)	2727136..2727258	+	123	WP_002404776.1	putative holin-like toxin	Toxin
- (2727324)	2727324..2727387	-	64	NuclAT_10	-	Antitoxin
- (2727191)	2727191..2727398	-	208	NuclAT_7	-	-
LQ065_RS13095 (2727444)	2727444..2727641	+	198	WP_002358966.1	type I toxin-antitoxin system toxin PepG1	-
- (2727574)	2727574..2727758	-	185	NuclAT_6	-	-
- (2727615)	2727615..2727758	-	144	NuclAT_9	-	-
LQ065_RS13100 (2727760)	2727760..2727900	+	141	WP_077143780.1	putative holin-like toxin	-
- (2727833)	2727833..2728034	-	202	NuclAT_4	-	-
LQ065_RS13105 (2728131)	2728131..2728274	+	144	WP_002396786.1	putative holin-like toxin	-
- (2728418)	2728418..2728467	+	50	NuclAT_11	-	-
- (2728206)	2728206..2728468	-	263	NuclAT_8	-	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (7-40)

Sequences

Toxin

Protein

• Length: 41 a.a.
• Molecular weight: 4396.44 Da
• Isoelectric Point: 10.2826

>T233039 WP_002404776.1 NZ_CP091240:2727136-2727258 [Enterococcus faecalis]
MKGVGLLSAYETIQTILGFGMFTIALIALIVKLLKEDKKK

Nucleotide

• Length: 123 bp

>T233039 NZ_CP128520:c2239275-2238886 [Mannheimia haemolytica]
ATGTATATGTTAGATACGAATACTGTAAGCTATTTTTTTCGTGGAAATGCAAATGTGGTGGCGAAATTGAAGTCCATTAA
TCCTGAGAGGCTTTGTATTTCATCTGTAACTGCTGCTGAATTGGTTTATGGTGTGGCGAAAAGAAATAATGGGCAGCTTT
CTCAATTTTTAGATTATTTTTTATCGAGTGTAAAGGTTTTAGATTGGAATTATCGTTGTGCTGAACTTTATGGAAAGTTA
CGGGCAGAGATGGAGAAAAATGGCAAAGTAATGGGCGTGCAGGATCAAATGATTGCTAGTCACGCTCTTGCTGAAGAGTG
TATTTTAGTTTCTAGTGATCAGGCATTTAAAATGGTACCTGATCTGAAATTGGAGAATTGGTTACACTAA

Antitoxin

Nucleotide

• Length: 64 bp

>AT233039 NZ_CP091240:c2727387-2727324 [Enterococcus faecalis]
TTGTGCTATAATAGCAATGAAAAGAGAGATATGCTGTAACATACCTCTCTAGTGTAGAGCCGTT

Structures

Toxin

• AlphaFold DB: S4BWW4

Antitoxin