Detailed information of TA system TA233032

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2632647..2632907
• Replicon: chromosome
• Accession: NZ_CP091240
• Organism: Enterococcus faecalis strain 249

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: LQ065_RS12650
• Protein ID: WP_156194032.1
• Coordinates: 2632764..2632907 (-)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2632647..2632831 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LQ065_RS12635 (2628208)	2628208..2628921	-	714	WP_002354877.1	trehalose operon repressor	-
LQ065_RS12640 (2629183)	2629183..2631927	+	2745	WP_002404790.1	glycosyl hydrolase family 65 protein	-
LQ065_RS12645 (2631942)	2631942..2632592	+	651	WP_002359015.1	beta-phosphoglucomutase	-
- (2632647)	2632647..2632831	+	185	NuclAT_5	-	Antitoxin
LQ065_RS12650 (2632764)	2632764..2632907	-	144	WP_156194032.1	type I toxin-antitoxin system toxin PepG1	Toxin
LQ065_RS12655 (2633138)	2633138..2634109	-	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
LQ065_RS12660 (2634284)	2634284..2634721	-	438	WP_002354871.1	peptide-methionine (R)-S-oxide reductase MsrB	-
LQ065_RS12665 (2634854)	2634854..2635408	-	555	WP_002359011.1	Maf family protein	-
LQ065_RS12670 (2635433)	2635433..2637565	-	2133	WP_085366626.1	DNA mismatch repair endonuclease MutL	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5327.50 Da
• Isoelectric Point: 10.8331

>T233032 WP_156194032.1 NZ_CP091240:c2632907-2632764 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTISLIALIVKLLKNDKKK

Nucleotide

• Length: 144 bp

>T233032 NZ_CP128520:c193929-193597 [Mannheimia haemolytica]
ATGAAACGTGGCGATATTTACTGGCTCGATCTTGATCCAACCTTAGGACACGAACAATCAGGCTTCCGCCCCGTTGTAAT
TGTTTCCGCAACTGCATTTAATCTAGCCAGTAAACTGCCTGTGGTTGTGCCGATTACTAACGGTGGAGCTTTTGCTGAAA
GACTGGGCTTTGCCGTTTCATTAAAAGATGCCGGCTTAAAAACAACAGGGATTATTCGATGCGATCAACCTCGCACAGTC
GATATTGCACAACGCCATGGAAAATTTATCGAAGCCTTACCCGAAAGCCTACTTGATGAAATTATGGCAAGGGTTTCAGT
GATTTTTGAGTAA

Antitoxin

Nucleotide

• Length: 185 bp

>AT233032 NZ_CP091240:2632647-2632831 [Enterococcus faecalis]
TGCTAGAATGTAGATGAAAAGAGAGAGATGCGTCAACATACCTCTCTGATGTAGAGCCGTTTGAGACGGTGACCAATTGT
ATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCA
ATCAAAGAAATGGTAAACATACCAA

Structures

Antitoxin