Detailed information of TA system TA233023

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2500794..2501192
• Replicon: chromosome
• Accession: NZ_CP091237
• Organism: Enterococcus faecalis strain 1521

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: LQ062_RS11875
• Protein ID: WP_023894767.1
• Coordinates: 2500794..2500898 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2501050..2501192 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LQ062_RS11860 (2496106)	2496106..2496819	-	714	WP_002354877.1	trehalose operon repressor	-
LQ062_RS11865 (2497080)	2497080..2499824	+	2745	WP_219259715.1	glycosyl hydrolase family 65 protein	-
LQ062_RS11870 (2499839)	2499839..2500489	+	651	WP_002419627.1	beta-phosphoglucomutase	-
- (2500518)	2500518..2500632	+	115	NuclAT_11	-	-
- (2500674)	2500674..2500861	+	188	NuclAT_4	-	-
LQ062_RS11875 (2500794)	2500794..2500898	-	105	WP_023894767.1	putative holin-like toxin	Toxin
- (2501050)	2501050..2501192	+	143	NuclAT_10	-	Antitoxin
LQ062_RS13140 (2501283)	2501283..2501405	-	123	WP_258536616.1	hypothetical protein	-
LQ062_RS11880 (2501946)	2501946..2502221	+	276	WP_224805966.1	CPBP family intramembrane metalloprotease	-
LQ062_RS11885 (2502277)	2502277..2503248	-	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
LQ062_RS11890 (2503423)	2503423..2503860	-	438	WP_002354871.1	peptide-methionine (R)-S-oxide reductase MsrB	-
LQ062_RS11895 (2503993)	2503993..2504547	-	555	WP_010816844.1	Maf family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-34)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3799.63 Da
• Isoelectric Point: 10.0079

>T233023 WP_023894767.1 NZ_CP091237:c2500898-2500794 [Enterococcus faecalis]
MSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Nucleotide

• Length: 105 bp

>T233023 NZ_CP128519:272900-273289 [Mannheimia haemolytica]
ATGTATATGTTAGATACGAATACTGTAAGCTATTTTTTTCGTGGAAATGCAAATGTGGTGGCGAAATTGAAGTCCATTAA
TCCTGAGAGGCTTTGTATTTCATCTGTAACTGCTGCTGAATTGGTTTATGGTGTGGCGAAAAGAAATAATGGGCAGCTTT
CTCAATTTTTAGATTATTTTTTATCGAGTGTAAAGGTTTTAGATTGGAATTATCGTTGTGCTGAACTTTATGGAAAGTTA
CGGGCAGAGATGGAGAAAAATGGCAAAGTAATGGGCGTGCAGGATCAAATGATTGCTAGTCACGCTCTTGCTGAAGAGTG
TATTTTAGTTTCTAGTGATCAGGCATTTAAAATGGTACCTGATCTGAAATTGGAGAATTGGTTACACTAA

Antitoxin

Nucleotide

• Length: 143 bp

>AT233023 NZ_CP091237:2501050-2501192 [Enterococcus faecalis]
TGTGCTATAATGAAAACGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGCAGAGCCGTTTAAGACGGTGACCGATT
TTGTTACAAAAAATAACCGTACCGATCAAAGTTGACGGTTATTTTTTATTGTCATTTTTAACA

Structures

Antitoxin