Detailed information of TA system TA233017

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-RNAII/-
• Location: 461342..461576
• Replicon: chromosome
• Accession: NZ_CP091237
• Organism: Enterococcus faecalis strain 1521

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: C7CXQ5
• Locus tag: LQ062_RS02285
• Protein ID: WP_002355568.1
• Coordinates: 461342..461458 (+)
• Length: 39 a.a.

Antitoxin (RNA)

Gene name	RNAII
Locus tag	-
Coordinates	461441..461576 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LQ062_RS02275 (456780)	456780..459038	+	2259	WP_002363179.1	DNA helicase PcrA	-
LQ062_RS02280 (459164)	459164..461194	+	2031	WP_002375948.1	NAD-dependent DNA ligase LigA	-
LQ062_RS02285 (461342)	461342..461458	+	117	WP_002355568.1	putative holin-like toxin	Toxin
- (461369)	461369..461574	-	206	NuclAT_3	-	-
- (461441)	461441..461576	-	136	NuclAT_9	-	Antitoxin
- (461441)	461441..461596	-	156	NuclAT_7	-	-
LQ062_RS02290 (461776)	461776..462081	+	306	WP_002355569.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
LQ062_RS02295 (462081)	462081..463550	+	1470	WP_002419989.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA	-
LQ062_RS02300 (463550)	463550..464980	+	1431	WP_002358703.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB	-
LQ062_RS02305 (464999)	464999..466087	+	1089	WP_002383001.1	diacylglycerol kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (3-35)

Sequences

Toxin

Protein

• Length: 39 a.a.
• Molecular weight: 4065.93 Da
• Isoelectric Point: 5.9482

>T233017 WP_002355568.1 NZ_CP091237:461342-461458 [Enterococcus faecalis]
MFLSVEAALGLMIGFATLVVTIIFGILALVLDNKNNRS

Nucleotide

• Length: 117 bp

>T233017 NZ_CP128518:c828835-828566 [Mannheimia haemolytica]
ATGCTACAAATTTCGCCGACAAACGCATATAAAAGAGACTTTAAAAAGATTGCAGCCGAATTAGTCGGTAGTTCGGAATA
TGTGGAAGTAATGTATTGCCTAATAAACCAATTACCATTGGCGGAAAAATATAGAGATCACCCACTACAAGGTGAATGGC
AAGGCTTTAGAGATTGCCATATTAAGCCTGATTTAGTGTTGATTTACGCTGTTGAAGATAATCTGCTCCGCCTTGTTCGT
TTAGGATCGCACGCTGAATTATTTGGATAA

Antitoxin

Nucleotide

• Length: 136 bp

>AT233017 NZ_CP091237:c461576-461441 [Enterococcus faecalis]
TGAAAAGAGAGATATGCAGGAACATACCTCTCTAATAGCCACTACCAGTTATAAGAACTGGTGGCTTACTGAGTTATTGG
TTTTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTT

Structures

Toxin

• AlphaFold DB: A0A1B4XLM6

Antitoxin