Detailed information of TA system TA233005

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2670310..2670534
• Replicon: chromosome
• Accession: NZ_CP091235
• Organism: Enterococcus faecalis strain 705

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: LQ054_RS12860
• Protein ID: WP_224561205.1
• Coordinates: 2670433..2670534 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2670310..2670488 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LQ054_RS12835	2665957..2666910	-	954	WP_002359060.1	siderophore ABC transporter substrate-binding protein	-
LQ054_RS12840	2666949..2667704	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
LQ054_RS12845	2667701..2668666	-	966	WP_002371665.1	iron chelate uptake ABC transporter family permease subunit	-
LQ054_RS12850	2668663..2669610	-	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
LQ054_RS12855	2669795..2670247	+	453	WP_002378807.1	YueI family protein	-
-	2670310..2670488	+	179	-	-	Antitoxin
LQ054_RS12860	2670433..2670534	-	102	WP_224561205.1	putative holin-like toxin	Toxin
LQ054_RS12865	2670725..2672995	-	2271	WP_002378809.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
LQ054_RS12870	2673166..2673672	+	507	WP_002378810.1	cysteine hydrolase family protein	-
LQ054_RS12875	2673862..2674758	+	897	WP_002365354.1	YitT family protein	-
LQ054_RS12880	2674809..2675207	-	399	WP_002354951.1	glyoxalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3629.37 Da
• Isoelectric Point: 4.5869

>T233005 WP_224561205.1 NZ_CP091235:c2670534-2670433 [Enterococcus faecalis]
MSIEATLELMISFAAFVALLIFGILEATKNDKK

Nucleotide

• Length: 102 bp

>T233005 NZ_CP128516:272872-273261 [Mannheimia haemolytica]
ATGTATATGTTAGATACGAATACTGTAAGCTATTTTTTTCGTGGAAATGCAAATGTGGTGGCGAAATTGAAGTCCATTAA
TCCTGAGAGGCTTTGTATTTCATCTGTAACTGCTGCTGAATTGGTTTATGGTGTGGCGAAAAGAAATAATGGGCAGCTTT
CTCAATTTTTAGATTATTTTTTATCGAGTGTAAAGGTTTTAGATTGGAATTATCGTTGTGCTGAACTTTATGGAAAGTTA
CGGGCAGAGATGGAGAAAAATGGCAAAGTAATGGGCGTGCAGGATCAAATGATTGCTAGTCACGCTCTTGCTGAAGAGTG
TATTTTAGTTTCTAGTGATCAGGCATTTAAAATGGTACCTGATCTGAAATTGGAGAATTGGTTACACTAA

Antitoxin

Nucleotide

• Length: 179 bp

>AT233005 NZ_CP091235:2670310-2670488 [Enterococcus faecalis]
AAAAGAGAGGTATGCGGGTACATACCTCTCCTTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTT
TTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCG
AAAATCAGTAGTGCAACAA

Structures

Antitoxin