Detailed information of TA system TA232988

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2860068..2860509
• Replicon: chromosome
• Accession: NZ_CP091231
• Organism: Enterococcus faecalis strain 732

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: E2Z0W4
• Locus tag: LQ055_RS14150
• Protein ID: WP_002381035.1
• Coordinates: 2860366..2860509 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2860068..2860269 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LQ055_RS14125	2855202..2856194	+	993	WP_002389493.1	biotin--[acetyl-CoA-carboxylase] ligase	-
LQ055_RS14130	2856458..2857096	-	639	WP_002378863.1	lytic polysaccharide monooxygenase	-
LQ055_RS14135	2857782..2859398	+	1617	WP_002389442.1	phosphatase PAP2/LCP family protein	-
LQ055_RS14140	2859727..2859876	+	150	WP_002411240.1	type I toxin-antitoxin system toxin PepG1	-
LQ055_RS14145	2859995..2860135	+	141	WP_073340360.1	putative holin-like toxin	-
-	2860068..2860269	-	202	-	-	Antitoxin
LQ055_RS14150	2860366..2860509	+	144	WP_002381035.1	putative holin-like toxin	Toxin
LQ055_RS14155	2860704..2864531	-	3828	WP_010816211.1	WxL domain-containing protein	-
LQ055_RS14160	2864518..2864880	-	363	WP_002378868.1	LPXTG cell wall anchor domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5202.20 Da
• Isoelectric Point: 10.0041

>T232988 WP_002381035.1 NZ_CP091231:2860366-2860509 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKENNKK

Nucleotide

• Length: 144 bp

>T232988 NZ_CP128511:c2125034-2124645 [Mannheimia haemolytica]
ATGTATATGTTAGATACGAATACTGTAAGCTATTTTTTTCGTGGAAATGCAAATGTGGTGGCGAAATTGAAGTCCATTAA
TCCTGAGAGGCTTTGTATTTCATCTGTAACTGCTGCTGAATTGGTTTATGGTGTGGCGAAAAGAAATAATGGGCAGCTTT
CTCAATTTTTAGATTATTTTTTATCGAGTGTAAAGGTTTTAGATTGGAATTATCGTTGTGCTGAACTTTATGGAAAGTTA
CGGGCAGAGATGGAGAAAAATGGCAAAGTAATGGGCGTGCAGGATCAAATGATTGCTAGTCACGCTCTTGCTGAAGAGTG
TATTTTAGTTTCTAGTGATCAGGCATTTAAAATGGTACCTGATCTGAAATTGGAGAATTGGTTACACTAA

Antitoxin

Nucleotide

• Length: 202 bp

>AT232988 NZ_CP091231:c2860269-2860068 [Enterococcus faecalis]
GTTTTTTTAGGTAATTGTGCTATAATAGCAATGAAAAGAGAGATATGCGCCAACATACCTCTCTGATGTAGAGCCGTTTA
AGACGGTGACCTTTTTGATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCA
ATTTCACAATCAGTGCAATCAAAGCAATGGTAAACATACCAA

Structures

Toxin

• AlphaFold DB: A0A2Z6BWH2

Antitoxin