Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2671896..2672232 Replicon chromosome
Accession NZ_CP091227
Organism Enterococcus faecalis strain 661

Toxin (Protein)


Gene name txpA Uniprot ID A0A1J6YG70
Locus tag LQ066_RS12865 Protein ID WP_002396786.1
Coordinates 2671896..2672039 (+) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2672183..2672232 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ066_RS12845 2667173..2667805 - 633 WP_002358972.1 RloB family protein -
LQ066_RS12850 2667814..2669109 - 1296 WP_002410675.1 ATP-binding protein -
LQ066_RS12855 2669571..2671187 + 1617 WP_002372620.1 phosphatase PAP2/LCP family protein -
LQ066_RS12860 2671516..2671665 + 150 WP_002411240.1 type I toxin-antitoxin system toxin PepG1 -
LQ066_RS12865 2671896..2672039 + 144 WP_002396786.1 putative holin-like toxin Toxin
- 2672183..2672232 + 50 - - Antitoxin
LQ066_RS12870 2672234..2676925 - 4692 WP_033918608.1 WxL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5203.19 Da        Isoelectric Point: 8.6626

>T232951 WP_002396786.1 NZ_CP091227:2671896-2672039 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKEDNKK

Download         Length: 144 bp

>T232951 NZ_CP128494:1373397-1373726 [Geobacillus stearothermophilus ATCC 12980]
ATGCAAGCGCCGGATCGTGGGGATCTTGTTTACGTCAATTTCAATCCACAAGCAGGGCATGAGCAGGCAGGAAAAAGGCC
CGGCATCGTTCTATCACCAAAGCGGTTCAATCAATTGACAGGGTTTGCGGTGCTTTGCCCGATCACCCAGCAACAAAAAG
GATATCCATTTGAAGTGGAATTGCCATCAGGCTTGGCCGTTGAAGGCGTGATTTTAACCGATCAGGTCAAAAGTTTAGAT
TGGCGCGCCCGACAGCTTCAAATAGTAGGACGGGCGCCCAATGAAGTTGTTTCGGATTGCTTGGATCTGATTCATACTTT
TCTTTCGTGA

Antitoxin


Download         Length: 50 bp

>AT232951 NZ_CP091227:2672183-2672232 [Enterococcus faecalis]
AATAAAAATGACCGAGCCTTAGAAAAATAAGAGGCTCGGGCATTTTTATT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J6YG70

Antitoxin

Download structure file

References