Detailed information of TA system TA232947

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2671598..2672039
• Replicon: chromosome
• Accession: NZ_CP091227
• Organism: Enterococcus faecalis strain 661

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A1J6YG70
• Locus tag: LQ066_RS12865
• Protein ID: WP_002396786.1
• Coordinates: 2671896..2672039 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2671598..2671799 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LQ066_RS12845	2667173..2667805	-	633	WP_002358972.1	RloB family protein	-
LQ066_RS12850	2667814..2669109	-	1296	WP_002410675.1	ATP-binding protein	-
LQ066_RS12855	2669571..2671187	+	1617	WP_002372620.1	phosphatase PAP2/LCP family protein	-
LQ066_RS12860	2671516..2671665	+	150	WP_002411240.1	type I toxin-antitoxin system toxin PepG1	-
-	2671598..2671799	-	202	-	-	Antitoxin
LQ066_RS12865	2671896..2672039	+	144	WP_002396786.1	putative holin-like toxin	Toxin
LQ066_RS12870	2672234..2676925	-	4692	WP_033918608.1	WxL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5203.19 Da
• Isoelectric Point: 8.6626

>T232947 WP_002396786.1 NZ_CP091227:2671896-2672039 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKEDNKK

Nucleotide

• Length: 144 bp

>T232947 NZ_CP128493:c397357-397070 [Novosphingobium resinovorum]
ATGGAGGTAACGCAAACTGCGGTCTTCGCGCAGTGGTTTCACCGTCTACGCGACCCAAAGGCGCAGTCCAGGATCGCGCA
GCGGATCGCTCGCATCGAGATCGGCCTGATGGGCGATGTGAAATCGGTGGGAGACGGCGTATCCGAAGCCCGCATCGATT
ATGGGCCGGGTTACCGGCTCTATTTCACGCGGCGCGGAGATGAGCTGGTTATCCTGCTGGTCGGCGGCGACAAGTCCTCC
CAGCAGCGGGATATCGCCAGAGCAAGGCAACTCGCGGCTCAGCTCTGA

Antitoxin

Nucleotide

• Length: 202 bp

>AT232947 NZ_CP091227:c2671799-2671598 [Enterococcus faecalis]
GTTTTTTTAGGTAATTGTGCTATAATAGCAATGAAAAGAGAGATATGCTGTAACATACCTCTCTGATGTAGAGCCGTTTA
AGACGGTGACCTTTTTGATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCA
ATTTCACAATCAGCGCAATCAAAGCAATGGTAAACATACCAA

Structures

Toxin

• AlphaFold DB: A0A1J6YG70

Antitoxin