Detailed information of TA system TA232941

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2521964..2522187
• Replicon: chromosome
• Accession: NZ_CP091227
• Organism: Enterococcus faecalis strain 661

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: LQ066_RS12180
• Protein ID: WP_075551663.1
• Coordinates: 2522086..2522187 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2521964..2522141 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LQ066_RS12155	2517611..2518564	-	954	WP_002370087.1	siderophore ABC transporter substrate-binding protein	-
LQ066_RS12160	2518603..2519358	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
LQ066_RS12165	2519355..2520320	-	966	WP_002354961.1	iron chelate uptake ABC transporter family permease subunit	-
LQ066_RS12170	2520317..2521264	-	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
LQ066_RS12175	2521449..2521901	+	453	WP_002354958.1	YueI family protein	-
-	2521964..2522141	+	178	-	-	Antitoxin
LQ066_RS12180	2522086..2522187	-	102	WP_075551663.1	putative holin-like toxin	Toxin
LQ066_RS12185	2522376..2524646	-	2271	WP_002370088.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
LQ066_RS12190	2524817..2525317	+	501	WP_002370089.1	cysteine hydrolase family protein	-
LQ066_RS12195	2525620..2526516	+	897	WP_002365354.1	YitT family protein	-
LQ066_RS12200	2526567..2526965	-	399	WP_002354951.1	glyoxalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3599.34 Da
• Isoelectric Point: 4.5869

>T232941 WP_075551663.1 NZ_CP091227:c2522187-2522086 [Enterococcus faecalis]
MSIEAALELMISFAAFVALLIFGILEATKNDKK

Nucleotide

• Length: 102 bp

>T232941 NZ_CP128487:c4887289-4886372 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin

Nucleotide

• Length: 178 bp

>AT232941 NZ_CP091227:2521964-2522141 [Enterococcus faecalis]
AAAAGAGAGGTATGCGGGTACATACCTCTCTTTTATACCAGCGCCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTT
TTATTACTGTTTAACCGTTCGGCCTGTCAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGA
AAATCAGTAGTGCAACAA

Structures

Antitoxin