Detailed information of TA system TA232910

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2033235..2033479
• Replicon: chromosome
• Accession: NZ_CP091198
• Organism: Enterococcus faecalis strain UK045

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: L2629_RS10755
• Protein ID: WP_021164572.1
• Coordinates: 2033235..2033363 (+)
• Length: 43 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2033274..2033479 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L2629_RS10745	2028685..2030943	+	2259	WP_002363179.1	DNA helicase PcrA	-
L2629_RS10750	2031069..2033099	+	2031	WP_002361258.1	NAD-dependent DNA ligase LigA	-
L2629_RS10755	2033235..2033363	+	129	WP_021164572.1	putative holin-like toxin	Toxin
-	2033274..2033479	-	206	-	-	Antitoxin
L2629_RS10760	2033681..2033986	+	306	WP_002355569.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
L2629_RS10765	2033986..2035455	+	1470	WP_002361259.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA	-
L2629_RS10770	2035455..2036885	+	1431	WP_002358703.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB	-
L2629_RS10775	2036904..2037992	+	1089	WP_002355572.1	diacylglycerol kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (7-39)

Sequences

Toxin

Protein

• Length: 43 a.a.
• Molecular weight: 4495.51 Da
• Isoelectric Point: 8.9940

>T232910 WP_021164572.1 NZ_CP091198:2033235-2033363 [Enterococcus faecalis]
MKGAMFLSVEAALGLMIGFATLVVTIIFVILALVLDNKNNRS

Nucleotide

• Length: 129 bp

>T232910 NZ_CP128464:2769966-2770100 [Enterococcus faecalis]
CTGAAAAATACGAATAAAAATATCGTTTACTGTACAACATATGAAACAATTCAGACGATCCTAGGGTTTGGTATGTTTAC
CATTGCTTTGATTGCACTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin

Nucleotide

• Length: 206 bp

>AT232910 NZ_CP091198:c2033479-2033274 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAGTAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAA
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Structures

Antitoxin