Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 1178519..1178852 Replicon chromosome
Accession NZ_CP091198
Organism Enterococcus faecalis strain UK045

Toxin (Protein)


Gene name txpA Uniprot ID Q82Z30
Locus tag L2629_RS06355 Protein ID WP_002387585.1
Coordinates 1178519..1178662 (+) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 1178594..1178852 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2629_RS06345 1173871..1173975 + 105 WP_021164545.1 putative holin-like toxin -
L2629_RS06345 1173871..1173975 + 105 WP_021164545.1 putative holin-like toxin -
L2629_RS06350 1174165..1177923 - 3759 WP_010706868.1 WxL domain-containing protein -
L2629_RS06350 1174165..1177923 - 3759 WP_010706868.1 WxL domain-containing protein -
L2629_RS06355 1178519..1178662 + 144 WP_002387585.1 putative holin-like toxin Toxin
L2629_RS06355 1178519..1178662 + 144 WP_002387585.1 putative holin-like toxin Toxin
L2629_RS06360 1178852..1181911 - 3060 WP_002387586.1 WxL domain-containing protein -
L2629_RS06360 1178852..1181911 - 3060 WP_002387586.1 WxL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5244.37 Da        Isoelectric Point: 10.5719

>T232903 WP_002387585.1 NZ_CP091198:1178519-1178662 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILKVVKEDKKK

Download         Length: 144 bp

>T232903 NZ_CP128464:568038-568154 [Enterococcus faecalis]
ATGTTGTTGTCCGTTGAAGCAGCGCTAGGACTGATGATTAGTTTTGCAATACTTGTTGTGACCATTATCTTCGGTATCTT
AGCGCTTGTCTTAGACAACAAAAATAACCGTTCATAA

Antitoxin


Download         Length: 259 bp

>AT232903 NZ_CP091198:c1178852-1178594 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTTAGAAAAATAAGAGGCTCGGGCATTTTTATTGATGGTCTTTTGATGGTCGTTGTGCTATA
ATAGCATTGAAAAGAGAGATATGCTGTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTGACCGATTTTGTTACAA
AAAATAACCGTACTCAGTCAAAGTAAACGGTTATTTTTTCTTGTCTTCTTTAACAACCTTTAGGATTCCGAAGATTAAAG
TCGCGATAAAAGAACCGAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A059MXV6

Antitoxin

Download structure file

References