Detailed information of TA system TA232889

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-RNAII/-
• Location: 1000502..1000761
• Replicon: chromosome
• Accession: NZ_CP091198
• Organism: Enterococcus faecalis strain UK045

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: L2629_RS05525
• Protein ID: WP_021164442.1
• Coordinates: 1000660..1000761 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	RNAII
Locus tag	-
Coordinates	1000502..1000706 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L2629_RS05495	995754..996707	-	954	WP_002370087.1	siderophore ABC transporter substrate-binding protein	-
L2629_RS05495	995754..996707	-	954	WP_002370087.1	siderophore ABC transporter substrate-binding protein	-
L2629_RS05500	996746..997501	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
L2629_RS05500	996746..997501	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
L2629_RS05505	997498..998463	-	966	WP_002387376.1	iron chelate uptake ABC transporter family permease subunit	-
L2629_RS05505	997498..998463	-	966	WP_002387376.1	iron chelate uptake ABC transporter family permease subunit	-
L2629_RS05510	998460..999407	-	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
L2629_RS05510	998460..999407	-	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
L2629_RS05515	999592..1000044	+	453	WP_002378959.1	YueI family protein	-
L2629_RS05515	999592..1000044	+	453	WP_002378959.1	YueI family protein	-
L2629_RS05520	1000226..1000327	-	102	WP_021164441.1	putative holin-like toxin	-
L2629_RS05520	1000226..1000327	-	102	WP_021164441.1	putative holin-like toxin	-
-	1000502..1000706	+	205	-	-	Antitoxin
-	1000502..1000706	+	205	-	-	Antitoxin
L2629_RS05525	1000660..1000761	-	102	WP_021164442.1	putative holin-like toxin	Toxin
L2629_RS05525	1000660..1000761	-	102	WP_021164442.1	putative holin-like toxin	Toxin
L2629_RS05530	1000952..1003222	-	2271	WP_002399785.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
L2629_RS05530	1000952..1003222	-	2271	WP_002399785.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
L2629_RS05535	1003393..1003893	+	501	WP_002378961.1	cysteine hydrolase family protein	-
L2629_RS05535	1003393..1003893	+	501	WP_002378961.1	cysteine hydrolase family protein	-
L2629_RS05540	1004454..1005350	+	897	WP_002354953.1	YitT family protein	-
L2629_RS05540	1004454..1005350	+	897	WP_002354953.1	YitT family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3625.38 Da
• Isoelectric Point: 4.5869

>T232889 WP_021164442.1 NZ_CP091198:c1000761-1000660 [Enterococcus faecalis]
MSIEATLELMISFATLVALLIFGILEATKNDKK

Nucleotide

• Length: 102 bp

>T232889 NZ_CP128449:c902548-902129 [Geobacillus stearothermophilus]
ATGAAAAGTGATGTCATTTTAAACAAGATCAGCGTGATCGAACGCTGCCTGAAACGAATTCGTGAAGAATATAACGGCGA
TCCAAAAAATTTACAAAATTACACAAAACAAGATTCGATCGTTCTGAATTTACAGCGGGCGTGCGAGGCATGCATCGATT
TGGCCATGCATATTGTGGCCGAGCAGAAATTCGGATTGCCGCAGCATAGCCGCGATGCATTCGCTCTCCTCGAAGAACAT
GGGGTCATCTCCCCTTCCATAAGCAAAAAGATGAAGGCGATGGTCGGATTCCGCAACATCGCCGTTCACGACTATCAACA
ACTGAACCTTGGCATCTTGCAAGCCATCGTCGAACACCATCTTGATGATTTCAAACAATTTACGAAAGCCATCCTCGATT
ATGCTAAGAAAAACAGCTAG

Antitoxin

Nucleotide

• Length: 205 bp

>AT232889 NZ_CP091198:1000502-1000706 [Enterococcus faecalis]
TTCCATTTTAAATAGAATTATGCTATTATGAAAATGAAAAGAGAGATATGCTACTACATACCTCTCCTTTATACCAACAC
CAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTT
ATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTA

Structures

Antitoxin