Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4404275..4404903 Replicon chromosome
Accession NZ_CP091122
Organism Serratia marcescens strain CM2012_028

Toxin (Protein)


Gene name higB Uniprot ID A0A8G2G488
Locus tag L2D51_RS21055 Protein ID WP_016930174.1
Coordinates 4404275..4404565 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag L2D51_RS21060 Protein ID WP_016930175.1
Coordinates 4404580..4404903 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2D51_RS21045 (L2D51_21045) 4400849..4402870 + 2022 WP_033639320.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
L2D51_RS21050 (L2D51_21050) 4402905..4404044 - 1140 WP_016930173.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
L2D51_RS21055 (L2D51_21055) 4404275..4404565 + 291 WP_016930174.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L2D51_RS21060 (L2D51_21060) 4404580..4404903 + 324 WP_016930175.1 HigA family addiction module antitoxin Antitoxin
L2D51_RS21065 (L2D51_21065) 4404896..4405408 + 513 WP_016930176.1 M48 family metallopeptidase -
L2D51_RS21070 (L2D51_21070) 4405458..4406438 + 981 WP_110147435.1 Gfo/Idh/MocA family oxidoreductase -
L2D51_RS21075 (L2D51_21075) 4406440..4407171 + 732 WP_016930178.1 glutamine amidotransferase -
L2D51_RS21080 (L2D51_21080) 4407424..4408392 + 969 WP_016930179.1 TerC family protein -
L2D51_RS21085 (L2D51_21085) 4408656..4409891 + 1236 WP_240293743.1 serine/threonine transporter SstT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(24-71)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11645.30 Da        Isoelectric Point: 10.2782

>T232782 WP_016930174.1 NZ_CP091122:4404275-4404565 [Serratia marcescens]
MIKSFRDRYLEQFYLEGRRSRLIPGALERQLARKLDMLAAAQQERDLHHPTGNYYKRLSGPFQGWSSLRVNMHWRLMFQW
RHDAAEKIYLDPHQDT

Download         Length: 291 bp

>T232782 NZ_CP128229:c1924265-1923894 [Paraburkholderia bonniea]
ATGATTCTCGTTGATACGTCAGTCTGGATCGACCACATCAACGCTTCTGATCCTATGTTGATTACCCTGCTTGCCGAGGA
GCGCGTGCTGGCTCATCCCTATGTGATAGGCGAGATTTCGCTCGGTAGTTTGCGTTCCCGTGATGTCGTGCTTGGCGCGT
TGCTCGACCTGCCGCGCGCTCCTGTTGCAACACCGGATGAGACGTTTTATCTGATCGAGCGCGAAGGCTTGTTCAATCGC
GGAATCGGATACGTCGACACGTCACTGCTGGCGTCCGCGCGCCTACAACCCGGCATTACCATCTGGACGCGCGATAAGCG
ATTGAAGAAGGTTGCCGATGAACTCAATCTCGGTGCAATGCTGGCGCACTAG

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12240.92 Da        Isoelectric Point: 6.7208

>AT232782 WP_016930175.1 NZ_CP091122:4404580-4404903 [Serratia marcescens]
MLETTTREPTTVGEVLQEEYLTPLGIGQEELAKVLGVTRATVNRLCNGHRRMSVAEANLFADLFETTADFWLNLQAAHDR
WEARQADAQRVRLRPIKEILRRNITHA

Download         Length: 324 bp

>AT232782 NZ_CP128229:c1924459-1924262 [Paraburkholderia bonniea]
ATGCGTACGACTATTGCGCTTGATGACGACTTGATCGCCAAGGCTCAAGCCTATACGGGCGTGAAGGAAAAAACGGCGCT
CGTGCGCGAAGCGCTAAAGGCCCTGATCCAGCGTGAAGCCGCGAAACGACTCGCAAATCTTGGCGGTAGCCAACCGGGCA
TCAAGGCCGCACCGCGTCGCCGGCAGAACGCCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References