Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3308991..3309651 Replicon chromosome
Accession NZ_CP091122
Organism Serratia marcescens strain CM2012_028

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag L2D51_RS15895 Protein ID WP_016927037.1
Coordinates 3309298..3309651 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A8G2G5Z5
Locus tag L2D51_RS15890 Protein ID WP_016927038.1
Coordinates 3308991..3309293 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2D51_RS15870 (L2D51_15870) 3304607..3305521 - 915 WP_016927041.1 branched-chain amino acid ABC transporter permease -
L2D51_RS15875 (L2D51_15875) 3305645..3306763 - 1119 WP_116403503.1 branched-chain amino acid ABC transporter substrate-binding protein -
L2D51_RS15885 (L2D51_15885) 3307368..3308576 - 1209 WP_079449935.1 aldose 1-epimerase family protein -
L2D51_RS15890 (L2D51_15890) 3308991..3309293 - 303 WP_016927038.1 XRE family transcriptional regulator Antitoxin
L2D51_RS15895 (L2D51_15895) 3309298..3309651 - 354 WP_016927037.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L2D51_RS15900 (L2D51_15900) 3310090..3311385 + 1296 WP_028127724.1 MFS transporter -
L2D51_RS15905 (L2D51_15905) 3311413..3312219 + 807 WP_048796852.1 substrate-binding domain-containing protein -
L2D51_RS15910 (L2D51_15910) 3312194..3313093 - 900 WP_016927033.1 LysR family transcriptional regulator -
L2D51_RS15915 (L2D51_15915) 3313197..3313562 - 366 WP_004935528.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-89)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13433.33 Da        Isoelectric Point: 8.4803

>T232777 WP_016927037.1 NZ_CP091122:c3309651-3309298 [Serratia marcescens]
VWEIKTTDAFDHWFRSLSDADRAGVLAALMVLREKGPGLPRPYADTVKGSRYSNMKELRIQCRGEPLRAFFAFDPYRIGI
VLCAGNKAGNEKRFYDGMIQVADREFTNWLNTLNEKE

Download         Length: 354 bp

>T232777 NZ_CP128219:89177-89518 [Escherichia coli]
ATGAAAACTTTACCTGCAATAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGCAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11093.96 Da        Isoelectric Point: 6.4738

>AT232777 WP_016927038.1 NZ_CP091122:c3309293-3308991 [Serratia marcescens]
MGRTLEQLIADEKPEVVAKAQALAADIMLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDIELPDGSHYEFVL

Download         Length: 303 bp

>AT232777 NZ_CP128219:88839-89156 [Escherichia coli]
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGAGATTACACTGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCTCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References