Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4099298..4099950 Replicon chromosome
Accession NZ_CP091121
Organism Serratia ureilytica strain CM2016_324

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag L2D49_RS19550 Protein ID WP_240289982.1
Coordinates 4099298..4099642 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag L2D49_RS19555 Protein ID WP_025304078.1
Coordinates 4099648..4099950 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2D49_RS19540 (L2D49_19540) 4095641..4097899 - 2259 WP_240289981.1 molybdopterin guanine dinucleotide-containing S/N-oxide reductase -
L2D49_RS19545 (L2D49_19545) 4098120..4099139 + 1020 WP_033652132.1 HTH-type transcriptional regulator GalR -
L2D49_RS19550 (L2D49_19550) 4099298..4099642 + 345 WP_240289982.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L2D49_RS19555 (L2D49_19555) 4099648..4099950 + 303 WP_025304078.1 helix-turn-helix transcriptional regulator Antitoxin
L2D49_RS19560 (L2D49_19560) 4099978..4101240 - 1263 WP_240289983.1 diaminopimelate decarboxylase -
L2D49_RS19565 (L2D49_19565) 4101374..4102297 + 924 WP_240289984.1 LysR family transcriptional regulator -
L2D49_RS19570 (L2D49_19570) 4102325..4103233 - 909 WP_033644836.1 LysR family transcriptional regulator -
L2D49_RS19575 (L2D49_19575) 4103342..4104226 + 885 WP_046687735.1 MBL fold metallo-hydrolase -
L2D49_RS19580 (L2D49_19580) 4104295..4104942 + 648 WP_033644834.1 DsbA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-104)

Antitoxin

HigA2-like, helix-turn-helix domain

(29-89)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13369.42 Da        Isoelectric Point: 10.8296

>T232763 WP_240289982.1 NZ_CP091121:4099298-4099642 [Serratia ureilytica]
MWQVVTVERFDDWFLALNNAQQTSILAAIFKLQTFGPQLARPHADTLHFSEAARQLKELRVQHRGRPFRVFFAFDPQRQA
VLLCGGDKTSDKRFYQRMLPIAAMEFSHYLATRR

Download         Length: 345 bp

>T232763 NZ_CP128218:c1712939-1712685 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11081.01 Da        Isoelectric Point: 10.3986

>AT232763 WP_025304078.1 NZ_CP091121:4099648-4099950 [Serratia ureilytica]
MAKPLSQLIDKLDPAVVAAARQKADKEIFELRLAMLREELAVSQVELAKRLGISQPSVANLEKRGSEIKLSSLKRYIEAM
GGTLSLDVQLPNGQHRRMTL

Download         Length: 303 bp

>AT232763 NZ_CP128218:c1713187-1712936 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References