Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3370059..3370719 Replicon chromosome
Accession NZ_CP091121
Organism Serratia ureilytica strain CM2016_324

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag L2D49_RS16090 Protein ID WP_197755856.1
Coordinates 3370366..3370719 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A8G2G5Z5
Locus tag L2D49_RS16085 Protein ID WP_016927038.1
Coordinates 3370059..3370361 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2D49_RS16065 (L2D49_16065) 3365673..3366587 - 915 WP_033643752.1 branched-chain amino acid ABC transporter permease -
L2D49_RS16070 (L2D49_16070) 3366712..3367830 - 1119 WP_016927040.1 branched-chain amino acid ABC transporter substrate-binding protein -
L2D49_RS16080 (L2D49_16080) 3368436..3369644 - 1209 WP_089192011.1 aldose 1-epimerase family protein -
L2D49_RS16085 (L2D49_16085) 3370059..3370361 - 303 WP_016927038.1 XRE family transcriptional regulator Antitoxin
L2D49_RS16090 (L2D49_16090) 3370366..3370719 - 354 WP_197755856.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L2D49_RS16095 (L2D49_16095) 3371158..3372453 + 1296 WP_033643756.1 MFS transporter -
L2D49_RS16100 (L2D49_16100) 3372480..3373286 + 807 WP_147838518.1 substrate-binding domain-containing protein -
L2D49_RS16105 (L2D49_16105) 3373261..3374160 - 900 WP_069100318.1 LysR family transcriptional regulator -
L2D49_RS16110 (L2D49_16110) 3374263..3374649 - 387 WP_223524775.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-89)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13506.43 Da        Isoelectric Point: 9.0587

>T232762 WP_197755856.1 NZ_CP091121:c3370719-3370366 [Serratia ureilytica]
VWEIKTTDAFDHWFRSLSDADRAGVLAALMVLREKGAGLPRPYADTVKGSRYSNMKELRIQCRGEPLRAFFAFDPYRIGI
VLCAGNKAGNEKRFYDRMIQVADREFTNWLNTLNEKE

Download         Length: 354 bp

>T232762 NZ_CP128218:1701043-1701417 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11093.96 Da        Isoelectric Point: 6.4738

>AT232762 WP_016927038.1 NZ_CP091121:c3370361-3370059 [Serratia ureilytica]
MGRTLEQLIADEKPEVVAKAQALAADIMLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDIELPDGSHYEFVL

Download         Length: 303 bp

>AT232762 NZ_CP128218:1700586-1700954 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References