Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4107311..4107963 Replicon chromosome
Accession NZ_CP091120
Organism Serratia marcescens strain CM2019_254

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag L2D50_RS19485 Protein ID WP_033652133.1
Coordinates 4107311..4107655 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag L2D50_RS19490 Protein ID WP_025304078.1
Coordinates 4107661..4107963 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2D50_RS19470 (L2D50_19470) 4103104..4103658 + 555 WP_025304075.1 hypothetical protein -
L2D50_RS19475 (L2D50_19475) 4103630..4105912 - 2283 WP_197791401.1 molybdopterin guanine dinucleotide-containing S/N-oxide reductase -
L2D50_RS19480 (L2D50_19480) 4106133..4107152 + 1020 WP_028127674.1 HTH-type transcriptional regulator GalR -
L2D50_RS19485 (L2D50_19485) 4107311..4107655 + 345 WP_033652133.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L2D50_RS19490 (L2D50_19490) 4107661..4107963 + 303 WP_025304078.1 helix-turn-helix transcriptional regulator Antitoxin
L2D50_RS19495 (L2D50_19495) 4107991..4109253 - 1263 WP_197791402.1 diaminopimelate decarboxylase -
L2D50_RS19500 (L2D50_19500) 4109387..4110310 + 924 WP_049208169.1 LysR family transcriptional regulator -
L2D50_RS19505 (L2D50_19505) 4110338..4111246 - 909 WP_025304081.1 LysR family transcriptional regulator -
L2D50_RS19510 (L2D50_19510) 4111355..4112239 + 885 WP_025304082.1 MBL fold metallo-hydrolase -
L2D50_RS19515 (L2D50_19515) 4112308..4112955 + 648 WP_025304083.1 DsbA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-104)

Antitoxin

HigA2-like, helix-turn-helix domain

(29-89)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13325.36 Da        Isoelectric Point: 10.8296

>T232747 WP_033652133.1 NZ_CP091120:4107311-4107655 [Serratia marcescens]
MWQVVTVERFDDWFLALNNAQQTSILAAIFKLQTFGPQLARPHADTLHFSDAARQLKELRVQHRGRPFRVFFAFDPQRQA
VLLCGGDKTGDKRFYQRMLPIAAMEFSHYLATRR

Download         Length: 345 bp

>T232747 NZ_CP128204:c2221836-2221537 [Vibrio furnissii]
ATGGCTGAAATAATCTGGACGGAGCCTGCGTTATCTGACCTTAATGATATTGCTGAATACATCGCGCTTGAAAATGTTGC
AGCTGCAAAGCAATTGGTTCAAACGATCTTCGCTAAAGTTGAACGCCTCGAAAATTTCCCCGAATCGGGTCGTATTCCGC
CCGAACTTGCACATCTCAGTTATCGTGAATTGGTCGTGAATCCATGCCGTATTTTCTATAAATTCGACGGCGATAAAGTG
TTTATTCTGTTTGTGATGCGTTCTGAGAGAGACTTGCGCAAGTTCCTGTTGGGCATGTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11081.01 Da        Isoelectric Point: 10.3986

>AT232747 WP_025304078.1 NZ_CP091120:4107661-4107963 [Serratia marcescens]
MAKPLSQLIDKLDPAVVAAARQKADKEIFELRLAMLREELAVSQVELAKRLGISQPSVANLEKRGSEIKLSSLKRYIEAM
GGTLSLDVQLPNGQHRRMTL

Download         Length: 303 bp

>AT232747 NZ_CP128204:c2222081-2221824 [Vibrio furnissii]
ATGAAAGTAGAACTCGTGACATCACTCAAACGTCAAGCCACGAAGATCCTTGCTGATCTCCGCAGCACAAAAGAACCTGT
ACTCATTACTGAACATGGTAAACCGTCGGCGTATCTAGTTGATGTTGAGGATTATGAGTTTATGCAAAATCGTTTGGCGA
TTCTGGAGGGCATTGCGCGGGGTGAACGTGCATTCGCTGATGGTAAAGTGGTGAGTCACGAGGAAGCCAAGGACAAAATG
TCAAAATGGCTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References