Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
Location | 845040..845770 | Replicon | chromosome |
Accession | NZ_CP091099 | ||
Organism | Pantoea agglomerans strain Pa58 |
Toxin (Protein)
Gene name | higB | Uniprot ID | - |
Locus tag | LZ609_RS07500 | Protein ID | WP_010258579.1 |
Coordinates | 845453..845770 (-) | Length | 106 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | LZ609_RS07495 | Protein ID | WP_245116454.1 |
Coordinates | 845040..845372 (-) | Length | 111 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LZ609_RS07475 (LZ609_07475) | 840418..841059 | + | 642 | WP_003849160.1 | protein phosphatase CheZ | - |
LZ609_RS07480 (LZ609_07480) | 841248..842399 | + | 1152 | WP_010258565.1 | flagellar biosynthesis protein FlhB | - |
LZ609_RS07485 (LZ609_07485) | 842392..844485 | + | 2094 | WP_010258569.1 | flagellar biosynthesis protein FlhA | - |
LZ609_RS07490 (LZ609_07490) | 844485..844877 | + | 393 | WP_050679619.1 | flagellar protein FlhE | - |
LZ609_RS07495 (LZ609_07495) | 845040..845372 | - | 333 | WP_245116454.1 | HigA family addiction module antitoxin | Antitoxin |
LZ609_RS07500 (LZ609_07500) | 845453..845770 | - | 318 | WP_010258579.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
LZ609_RS07505 (LZ609_07505) | 845845..846843 | - | 999 | WP_245116456.1 | aldo/keto reductase | - |
LZ609_RS07510 (LZ609_07510) | 847056..847991 | - | 936 | WP_245116458.1 | LysR family transcriptional regulator | - |
LZ609_RS07515 (LZ609_07515) | 848079..849809 | - | 1731 | WP_010258588.1 | arginine--tRNA ligase | - |
LZ609_RS22810 | 850020..850142 | - | 123 | WP_009089698.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 106 a.a. Molecular weight: 12357.17 Da Isoelectric Point: 10.1380
>T232723 WP_010258579.1 NZ_CP091099:c845770-845453 [Pantoea agglomerans]
VATLRNIESFRDDWLKDYFLYGKFSKRIPSSLSSALARKLDMINAAINYKDLRSPPGNRYEELNPPLKGYASIRVNEQYR
LIFKWIEGKAVDLYLDAHSYKTHKR
VATLRNIESFRDDWLKDYFLYGKFSKRIPSSLSSALARKLDMINAAINYKDLRSPPGNRYEELNPPLKGYASIRVNEQYR
LIFKWIEGKAVDLYLDAHSYKTHKR
Download Length: 318 bp
>T232723 NZ_CP128191:363811-364179 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA
Antitoxin
Download Length: 111 a.a. Molecular weight: 12587.47 Da Isoelectric Point: 5.1473
>AT232723 WP_245116454.1 NZ_CP091099:c845372-845040 [Pantoea agglomerans]
MNQATRKPTTVGDVLLYEYLEPTGLKILDLAEMLKVHRNTVSALVNNNRKLTPDMAFRLAAAFETSVEFWLNLQNSVDIW
EVMHDAKAQEEISRVTPLKDFLVQKENQLA
MNQATRKPTTVGDVLLYEYLEPTGLKILDLAEMLKVHRNTVSALVNNNRKLTPDMAFRLAAAFETSVEFWLNLQNSVDIW
EVMHDAKAQEEISRVTPLKDFLVQKENQLA
Download Length: 333 bp
>AT232723 NZ_CP128191:363593-363814 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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