Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 845040..845770 Replicon chromosome
Accession NZ_CP091099
Organism Pantoea agglomerans strain Pa58

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LZ609_RS07500 Protein ID WP_010258579.1
Coordinates 845453..845770 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LZ609_RS07495 Protein ID WP_245116454.1
Coordinates 845040..845372 (-) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ609_RS07475 (LZ609_07475) 840418..841059 + 642 WP_003849160.1 protein phosphatase CheZ -
LZ609_RS07480 (LZ609_07480) 841248..842399 + 1152 WP_010258565.1 flagellar biosynthesis protein FlhB -
LZ609_RS07485 (LZ609_07485) 842392..844485 + 2094 WP_010258569.1 flagellar biosynthesis protein FlhA -
LZ609_RS07490 (LZ609_07490) 844485..844877 + 393 WP_050679619.1 flagellar protein FlhE -
LZ609_RS07495 (LZ609_07495) 845040..845372 - 333 WP_245116454.1 HigA family addiction module antitoxin Antitoxin
LZ609_RS07500 (LZ609_07500) 845453..845770 - 318 WP_010258579.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LZ609_RS07505 (LZ609_07505) 845845..846843 - 999 WP_245116456.1 aldo/keto reductase -
LZ609_RS07510 (LZ609_07510) 847056..847991 - 936 WP_245116458.1 LysR family transcriptional regulator -
LZ609_RS07515 (LZ609_07515) 848079..849809 - 1731 WP_010258588.1 arginine--tRNA ligase -
LZ609_RS22810 850020..850142 - 123 WP_009089698.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(7-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(24-70)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12357.17 Da        Isoelectric Point: 10.1380

>T232723 WP_010258579.1 NZ_CP091099:c845770-845453 [Pantoea agglomerans]
VATLRNIESFRDDWLKDYFLYGKFSKRIPSSLSSALARKLDMINAAINYKDLRSPPGNRYEELNPPLKGYASIRVNEQYR
LIFKWIEGKAVDLYLDAHSYKTHKR

Download         Length: 318 bp

>T232723 NZ_CP128191:363811-364179 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12587.47 Da        Isoelectric Point: 5.1473

>AT232723 WP_245116454.1 NZ_CP091099:c845372-845040 [Pantoea agglomerans]
MNQATRKPTTVGDVLLYEYLEPTGLKILDLAEMLKVHRNTVSALVNNNRKLTPDMAFRLAAAFETSVEFWLNLQNSVDIW
EVMHDAKAQEEISRVTPLKDFLVQKENQLA

Download         Length: 333 bp

>AT232723 NZ_CP128191:363593-363814 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References