Detailed information of TA system TA232722

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 672640..673300
• Replicon: chromosome
• Accession: NZ_CP091099
• Organism: Pantoea agglomerans strain Pa58

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A349IFT5
• Locus tag: LZ609_RS06665
• Protein ID: WP_010670918.1
• Coordinates: 672640..672993 (+)
• Length: 118 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: LZ609_RS06670
• Protein ID: WP_010247918.1
• Coordinates: 672998..673300 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LZ609_RS06645 (LZ609_06645)	667837..668118	+	282	WP_010247933.1	hypothetical protein	-
LZ609_RS06650 (LZ609_06650)	668217..668618	+	402	WP_010247930.1	cell envelope integrity TolA C-terminal domain-containing protein	-
LZ609_RS06655 (LZ609_06655)	668695..670857	-	2163	WP_245116397.1	ferric-rhodotorulic acid/ferric-coprogen receptor FhuE	-
LZ609_RS06660 (LZ609_06660)	671253..672341	+	1089	WP_029519393.1	YncE family protein	-
LZ609_RS06665 (LZ609_06665)	672640..672993	+	354	WP_010670918.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LZ609_RS06670 (LZ609_06670)	672998..673300	+	303	WP_010247918.1	XRE family transcriptional regulator	Antitoxin
LZ609_RS06680 (LZ609_06680)	673972..674895	+	924	WP_122458171.1	sugar ABC transporter substrate-binding protein	-
LZ609_RS06685 (LZ609_06685)	674928..676412	+	1485	WP_033758305.1	sugar ABC transporter ATP-binding protein	-
LZ609_RS06690 (LZ609_06690)	676436..677461	+	1026	WP_170933484.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-106)

Antitoxin

• HigA2-like, helix-turn-helix domain (18-89)

Sequences

Toxin

Protein

• Length: 118 a.a.
• Molecular weight: 13649.71 Da
• Isoelectric Point: 8.4949

>T232722 WP_010670918.1 NZ_CP091099:672640-672993 [Pantoea agglomerans]
VWMIKTTERFDRWFTLLNESDRACVLAALMVLREKGPGLSRPYADTLKGSVYINMKELRIQSRGDPIRAFFAFDPNRTAI
VLCAGNKVGNEKRFYQEMLPVADREFTHWLNSFKDEE

Nucleotide

• Length: 354 bp

>T232722 NZ_CP128189:14919-15782 [Enterococcus faecium]
ATGGCAAATATAGTCAATTTTACTGACAAACAATTTGAGAATCGCTTAAATGATAATTTAGAAGAATTGATTCAAGGAAA
AAAAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGGCAACCAGGGTCAGGGAAAACCAGTTTGCGATCAGCAATTT
TTGAAGAAACACAAGGGAATGTTATTGTCATTGATAATGATACCTTTAAACAACAGCACCCTAATTTTGATGAACTAGTG
AAACTTTATGAAAAAGACGTAGTAAAACACGTTACCCCTTATTCTAATCGCATGACAGAAGCGATCATAAGCCGTTTGAG
CGATCAAGGGTATAATTTGGTGATCGAAGGTACAGGACGAACAACAGACGTTCCTATTCAAACCGCAACAATGCTTCAAG
CCAAAGGTTATGAAACAAAAATGTATGTCATGGCAGTACCTAAAATCAACTCATATTTAGGAACAATTGAACGATATGAA
ACCATGTATGCAGATGATCCAATGACAGCCAGGGCAACACCAAAACAAGCGCATGATATTGTTGTCAAAAACTTACCGAC
CAATTTAGAAACCCTTCATAAAACGGGCTTATTTAGCGATATAAGGCTATATAACAGAGAAGGAGTAAAACTCTATTCAA
GTTTGGAAACACCTTCTATTAGTCCAAAAGAAACCTTAGAAAAAGAATTGAATCGTAAAGTATCAGGGAAAGAAATTCAA
CCGACTTTAGAACGAATAGAGCAAAAAATGGTTCTAAATAAACACCAAGAGACACCTGAATTTAAAGCAATTCAACAAAA
ATTGGAAAGCTTGCAGCCACCTACACCACCAATACCCAAAACACCTAAACTTCCAGGTATTTAA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 10941.72 Da
• Isoelectric Point: 5.7251

>AT232722 WP_010247918.1 NZ_CP091099:672998-673300 [Pantoea agglomerans]
MGRTLEQLIADEKPEVVADAQAMATDILLNIHLAELREKVQKTQVEMAKALGITQPTVAGMEKPGRDLKLSTLKRYIDAA
GGKLRLVVELPDGSHYGFEV

Nucleotide

• Length: 303 bp

>AT232722 NZ_CP128189:14645-14917 [Enterococcus faecium]
ATGGCAGTTACGTATGAAAAAACATTTGAAATAGAGATCATTAACGAATTATCGGCAAGCGTTTATAATCGAGTATTAAA
CTATGTTTTGAACCATGAATTAAATAAAAATGACTCTCAATTATTGGAAGTCAATTTATTAAACCAATTAAAGCTTGCAA
AACGTGTAAATCTTTTTGATTATTCTTTAGAAGAATTACAAGCCGTTCATGAGTATTGGCGGTCAATGAATCGTTACTCA
AAACAAGTTTTGAATAAAGAGAAAGTGGCTTAA

Structures

Toxin

• AlphaFold DB: A0A349IFT5