Detailed information of TA system TA232718

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 45776..46278
• Replicon: plasmid p2
• Accession: NZ_CP091098
• Organism: Pantoea agglomerans strain Pa58

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: A0A8X8DPE2
• Locus tag: LZ609_RS02865
• Protein ID: WP_010256862.1
• Coordinates: 45776..46030 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A349IE86
• Locus tag: LZ609_RS02870
• Protein ID: WP_010256861.1
• Coordinates: 46027..46278 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LZ609_RS02850 (LZ609_02850)	41769..42062	-	294	WP_033786403.1	DUF1493 family protein	-
LZ609_RS02855 (LZ609_02855)	42056..42514	-	459	WP_245115380.1	hypothetical protein	-
LZ609_RS02860 (LZ609_02860)	43174..45720	+	2547	WP_122460001.1	excinuclease ABC subunit UvrA	-
LZ609_RS02865 (LZ609_02865)	45776..46030	-	255	WP_010256862.1	Txe/YoeB family addiction module toxin	Toxin
LZ609_RS02870 (LZ609_02870)	46027..46278	-	252	WP_010256861.1	YoeB-YefM toxin-antitoxin system antitoxin YefM	Antitoxin
LZ609_RS02875 (LZ609_02875)	46463..47302	-	840	WP_010256859.1	MBL fold metallo-hydrolase	-
LZ609_RS02880 (LZ609_02880)	47470..48783	-	1314	WP_010256858.1	CitMHS family transporter	-
LZ609_RS02885 (LZ609_02885)	49125..50576	-	1452	WP_245115348.1	flagellin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Mobilizable plasmid	-	-	1..206494	206494

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9782.16 Da
• Isoelectric Point: 9.3799

>T232718 WP_010256862.1 NZ_CP091098:c46030-45776 [Pantoea agglomerans]
VKLTWSAEAWEDYLYWQDADKKTVKKINELLKDASRTPFEGKGKPEPLKHNLAGFWSRRITAEHRLVYAVSGDALLIASC
RYHY

Nucleotide

• Length: 255 bp

>T232718 NZ_CP128184:1218747-1219493 [Bacillus velezensis]
ATGCTTTTGTTTTTTCAGATCATGGTGTGGACGATGGCGGCCGCACTCATTTTATATGTGTACGCATCCTGGCGGTATGA
GGCAAAGGTGAAAGAAAAAATGTTTGCCATCCGTAAAACGTGGTATTTACTATTTGTACTGGGCTCCATGGTCTATTGGA
CATATGATCCTGAATCGCTCTTTGCCGCATGGAGACAATATTTGATTGTTGCCGTCTGCTTTGCCCTTATTGATGCGTTT
ATCTTTTTGAGCGCGTATATCAAAAAGCTCGCCGGCAATGAATTAGAGACGGATACGCGGGAAATTTTAGAAGAAAATAA
CGAAATGCTTCACTCCTATCTTGAAAAACTGAAAACCTATCAATATCTGTTGAAAAATGAACCGATCCATGTATATTATG
GAAGTACAGAAGCTTATGCGGAAGGCATCAGCAGACTGCTGGCCGCTTATGCCGAAAAAATGAATGTCACGGCTTCCTTG
TGCGACTATTCCGCACAATCGGATAAGGACCGCTTGACGGAGCATATGCCTGATGCGGCAGACGTTCAGTCCCGTCTTAA
CCGTAAAGACGTCTACTATGATCAAAAAGGCAGGCTTGTGCTTATTCCGTTTACAGTCCAGAACCGCCATTACGTGATCA
AACTCACGTCGGAAAACCTGTTGACGGAATTCGATTATTTGCTTTTCACATCGCTAACAAGCATTTATGATTTAATGCTG
CCAATAGAAGAGGAAGGTGACGGTTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9339.48 Da
• Isoelectric Point: 4.4155

>AT232718 WP_010256861.1 NZ_CP091098:c46278-46027 [Pantoea agglomerans]
MRAISYSEARQNLSATMVQTVEDKAPVLITRQNGESCVLMSLEEYNSLEETAYLLRSPKNARRLMDSIESLQSGNGTDRD
IIE

Nucleotide

• Length: 252 bp

>AT232718 NZ_CP128184:1219494-1219664 [Bacillus velezensis]
ATGGAGCAGGCATTTCAAAACGGGCAGCCGGAACAAAGAGCGAAACCGTTCAAAATGTTTAAAAAACGTTCAATGACAAG
TATCGCAAGTTACCAGGTCAGCCCTCATACCGCCAGAATTTTCAAAGAAAACGAGCGGCTGATTGACAAGTATAAACAAA
AAAAAGCTTGA

Structures

Antitoxin

• AlphaFold DB: A0A349IE86