Detailed information of TA system TA232697

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 5041567..5042156
• Replicon: chromosome
• Accession: NZ_CP091078
• Organism: Xanthomonas arboricola pv. pruni strain R1

Toxin (Protein)

• Gene name: graT
• Uniprot ID: A0A2S7AZR2
• Locus tag: K9U01_RS21670
• Protein ID: WP_039429225.1
• Coordinates: 5041875..5042156 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: K9U01_RS21665
• Protein ID: WP_006449989.1
• Coordinates: 5041567..5041857 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K9U01_RS21645 (K9U01_21645)	5037709..5038545	+	837	WP_081327584.1	restriction endonuclease	-
K9U01_RS21650 (K9U01_21650)	5038620..5040518	+	1899	WP_126750750.1	hypothetical protein	-
K9U01_RS21655 (K9U01_21655)	5040692..5041024	+	333	WP_039513672.1	lipoprotein	-
K9U01_RS21660 (K9U01_21660)	5041174..5041376	+	203	Protein_4240	hypothetical protein	-
K9U01_RS21665 (K9U01_21665)	5041567..5041857	-	291	WP_006449989.1	HigA family addiction module antitoxin	Antitoxin
K9U01_RS21670 (K9U01_21670)	5041875..5042156	-	282	WP_039429225.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
K9U01_RS21675 (K9U01_21675)	5042296..5044422	-	2127	WP_043087609.1	exodeoxyribonuclease V subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-93)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (6-82)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11046.72 Da
• Isoelectric Point: 9.7972

>T232697 WP_039429225.1 NZ_CP091078:c5042156-5041875 [Xanthomonas arboricola pv. pruni]
MIRSFVDKEAEKIWLGERSRRLPADIQSVARRKLRMLNAAAHLDDLRIPPANRLEALKGERRGQYSIRINDQWRICFRWM
EGDVAEVEIVDYH

Nucleotide

• Length: 282 bp

>T232697 NZ_CP128112:2375399-2376139 [Bacillus mycoides]
TTGACGATCTCTAACATTCGAATTGGCTTATTTATTTTAGCAATCGTCTTTATTGTTCTTGTTTTCTTTTATTGGAGAAA
TGAAGAGTTGTACGAGGAGAAGAAACAACGAATTCGAAAAACGTGGTACGGTTTGTTCATAACATCAGTCACAGTTTATT
TCATGATAAAAGGAATAGATTTAACCCTCTGGAAAAATCTTTTAATGTTTACTGCGATGGTAATTTTCGTTGATATTGCA
TTCATTTTGACACCAAATATTTCAGAAATATGGGGCGCAAAATTCAGCGATATTGGAAAGACAGTCCAATCAATTAAAAG
GTCATTAATTGCTTCAAAAGCAAGAGGAGAAATATATACGACAATTATTCAAAATGTGAATCCAACAGCCTTTGGGACAA
TGGAATGGCATACGGAAGAGGAATATACAAAAAGCTTAAACACATTTTTAGATTCATATGGGGAAAAGATTGGTGCGAAA
ATTGTTGTATTTGAAGCGGTGAAGGAATTAAATACAAACTTTCGTGGTATCCGCTCTCAATTTAGTATTATTGTTCCATT
AGAACACATCGAGCAATTGAATGAGCAGAAAGCGGTGCAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTTAGTG
ATGTTTTCATTGTTATTGATGGGAAGAAAAATAACCTTCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATTCAT
CATAGTTATTTTAGTAAATAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10540.20 Da
• Isoelectric Point: 6.4664

>AT232697 WP_006449989.1 NZ_CP091078:c5041857-5041567 [Xanthomonas arboricola pv. pruni]
MTVLPNIHPGEILLEEFLEPMGISQNALARATDVPPRRINEIVLGKRGITADTAVRLAAALGTTERFWLGLQADYELEQA
HRALGDLPSRIKRLAA

Nucleotide

• Length: 291 bp

>AT232697 NZ_CP128112:2376252-2376377 [Bacillus mycoides]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCTTTAATAAAAGGAGATAC
TTTGCAGCAAGTAGAAGAGTTAGAAGAAGAATTAAAAAGAAAATGA

Structures

Toxin

• AlphaFold DB: A0A2S7AZR2