232658

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 2370032..2370686 Replicon chromosome
Accession NZ_CP091067
Organism Pseudomonas sp. BC42

Toxin (Protein)


Gene name higB Uniprot ID A0A0D6BLD7
Locus tag L1O02_RS11025 Protein ID WP_060840140.1
Coordinates 2370336..2370686 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0D6BLA0
Locus tag L1O02_RS11020 Protein ID WP_060840141.1
Coordinates 2370032..2370349 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1O02_RS11000 (L1O02_11000) 2365335..2366087 - 753 WP_060840145.1 UDP-2,3-diacylglucosamine diphosphatase -
L1O02_RS11005 (L1O02_11005) 2366084..2366587 - 504 WP_060840144.1 peptidylprolyl isomerase -
L1O02_RS11010 (L1O02_11010) 2366858..2368558 + 1701 WP_108545748.1 glutamine--tRNA ligase/YqeY domain fusion protein -
L1O02_RS11015 (L1O02_11015) 2368577..2369959 + 1383 WP_060840142.1 cysteine--tRNA ligase -
L1O02_RS11020 (L1O02_11020) 2370032..2370349 - 318 WP_060840141.1 XRE family transcriptional regulator Antitoxin
L1O02_RS11025 (L1O02_11025) 2370336..2370686 - 351 WP_060840140.1 hypothetical protein Toxin
L1O02_RS11030 (L1O02_11030) 2370924..2372387 - 1464 WP_015636299.1 NADH-quinone oxidoreductase subunit NuoN -
L1O02_RS11035 (L1O02_11035) 2372395..2373927 - 1533 WP_016965722.1 NADH-quinone oxidoreductase subunit M -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(48-101)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 14022.12 Da        Isoelectric Point: 8.9935

>T232658 WP_060840140.1 NZ_CP091067:c2370686-2370336 [Pseudomonas sp. BC42]
MNALFIELPAFARYRRDFLDDELFCELQIELLRHPHAGVLIQGTGGLRKMRFIDERRNKGRRGGLRVIYYWWSGGAQFWL
FTLFDKEQMDDLLPQQRQQLKQLLEREIEARRHDQT

Download         Length: 351 bp

>T232658 NZ_CP127869:1008220-1008402 [Staphylococcus epidermidis]
ATGGCGAACAAAAAAGATTCCAAATTAAATTATCATGAAGAAGAAAACGCTATGGTGACTGACTTAGATGATTTAAAAGA
ATTAGGAAAAGAAATGGAACAGATTTCACAGGAAAATGATGAAGAAAAATTAAATCAACCTCATGATAACGAAGTTCGTT
CAGATTTTAAAAACAGTAAATAG

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 12067.91 Da        Isoelectric Point: 10.7043

>AT232658 WP_060840141.1 NZ_CP091067:c2370349-2370032 [Pseudomonas sp. BC42]
MTKRDIFSELVEGIDALTQERQGKITLRSHKVKLDKLPPITATEVMNIRQQLNLSRSVFAMYLRTNTRTLENWEQGRATP
NAQATTLIRLVQRYPDTVERLASLA

Download         Length: 318 bp

>AT232658 NZ_CP127869:1007597-1008196 [Staphylococcus epidermidis]
ATGGCAATGAATTTTAAAGTATTTGACAATAGTGAAAAAGTAGCAGAATATACTGCAGATATTCTACGTAAGCAGTTTAA
TAATAATCCAACTACTATTGCAGGATTTCATTTAGGCAAAGAACATGCACCAGTGTTTGATGAACTTAAGAAAAATGTGG
AAAATCATGCAGTTGATTTCAGTCAAATAAATATTTTAGATTATGATGATAATCATTCTTATTATGAGGCTTTGGGTGTG
CCAACAGGCCAAATTTATTCAATTTCTTACGAAAATAATGCAATTGACTTTATCTCAGATAAGATTAAGACTAAAGAAAA
TAAGGGAAAACTGACAATGCAAGTCCTTACGATTGATGAAAATGGCAAACTTGACGTTAGCGTTCGTCAAGGTTTGATGG
AAGCTAGAGAAATTTTCTTAATTATTACCGGTGCTAATAAACGCGATATGGTAGAAAAACTTTACCGTGAAAATGGTAAG
ACTAGTTTTGAACCATCGGATTTAAAAGCACACCGTATGGTCAATGTTATCTTAGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGACGTAAAAGAGTACTTCACTGCACGTTTTGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6BLD7

Antitoxin

Source ID Structure
AlphaFold DB A0A0D6BLA0

References