232657

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2465648..2466171 Replicon chromosome
Accession NZ_CP091066
Organism Staphylococcus aureus strain UMCG579

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag L1O91_RS12140 Protein ID WP_054189905.1
Coordinates 2465648..2465914 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag L1O91_RS12145 Protein ID WP_020977565.1
Coordinates 2465914..2466171 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1O91_RS12120 (2460856) 2460856..2462043 - 1188 WP_054189907.1 MFS transporter -
L1O91_RS12125 (2462437) 2462437..2463213 - 777 WP_000072151.1 iron export ABC transporter permease subunit FetB -
L1O91_RS12130 (2463206) 2463206..2463868 - 663 WP_025786559.1 ATP-binding cassette domain-containing protein -
L1O91_RS12135 (2464218) 2464218..2465294 - 1077 WP_054189906.1 M42 family metallopeptidase -
L1O91_RS12140 (2465648) 2465648..2465914 - 267 WP_054189905.1 Txe/YoeB family addiction module toxin Toxin
L1O91_RS12145 (2465914) 2465914..2466171 - 258 WP_020977565.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
L1O91_RS12150 (2466531) 2466531..2466986 + 456 WP_000732082.1 DUF1307 domain-containing protein -
L1O91_RS12155 (2467154) 2467154..2468731 - 1578 WP_054189904.1 FMN-binding glutamate synthase family protein -
L1O91_RS12160 (2468926) 2468926..2469675 + 750 WP_054189903.1 CPBP family lipoprotein N-acylation protein LnsB -
L1O91_RS12165 (2469899) 2469899..2471092 - 1194 WP_006191034.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10587.19 Da        Isoelectric Point: 10.1603

>T232657 WP_054189905.1 NZ_CP091066:c2465914-2465648 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKITHPYLKKTFIEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRGVYTIDDRNKVVLI
LSAWSHYD

Download         Length: 267 bp

>T232657 NZ_CP127869:842950-843312 [Staphylococcus epidermidis]
ATGATTAGAAGAGGAGATGTTTATTTAGCGGATTTATCACCAGTTCAAGGGTCTGAACAAGGGGGAGTAAGACCTGTAGT
TATCATTCAAAATGATACTGGTAATAAATATAGTCCAACTGTAATTGTAGCTGCGATTACTGGTAGGATTAATAAAGCGA
AAATACCAACCCACGTAGAAATTGAAAAGAAAAAGTATAAATTAGACAAAGATTCAGTTATTCTTCTTGAACAAATTAGA
ACACTAGATAAAAAGCGTTTAAAAGAAAAATTAACATTTTTATCAGAGAGTAAAATGATAGAGGTTGATAATGCCTTAGA
TATTAGTTTGGGATTAAATAACTTTGATCATCATAAATCTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9796.79 Da        Isoelectric Point: 4.3304

>AT232657 WP_020977565.1 NZ_CP091066:c2466171-2465914 [Staphylococcus aureus]
MIITSPTEARKHFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT232657 NZ_CP127869:842783-842953 [Staphylococcus epidermidis]
ATGTTATCTTTTAATCAAAATAGAAACCACAGTCTTGAACAATCTTTAAAAGAAGGTTATGCACAAATGGCCGATTTAAA
CCTCTCCCTAGCAACAGAAGCTTTCCCGATAGAGTGTGAAGCTTGTGATTGCAATGAATCACATTTAATATCTAATTCAA
AGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References