Detailed information of TA system TA232655

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2434334..2434518
• Replicon: chromosome
• Accession: NZ_CP091066
• Organism: Staphylococcus aureus strain UMCG579

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2K4AFL5
• Locus tag: L1O91_RS12000
• Protein ID: WP_000482651.1
• Coordinates: 2434411..2434518 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2434334..2434394 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L1O91_RS11975	2429878..2430993	-	1116	WP_054189927.1	pyridoxal phosphate-dependent aminotransferase family protein	-
L1O91_RS11980	2430971..2431978	-	1008	WP_001046647.1	biotin synthase BioB	-
L1O91_RS11985	2431980..2433338	-	1359	WP_054189926.1	adenosylmethionine--8-amino-7-oxononanoate transaminase	-
L1O91_RS11990	2433316..2434002	-	687	WP_054189925.1	dethiobiotin synthase	-
L1O91_RS11995	2434057..2434224	-	168	Protein_2315	hypothetical protein	-
-	2434334..2434394	+	61	-	-	Antitoxin
L1O91_RS12000	2434411..2434518	-	108	WP_000482651.1	type I toxin-antitoxin system Fst family toxin	Toxin
L1O91_RS12005	2434652..2435038	-	387	WP_054189924.1	flippase GtxA	-
L1O91_RS12010	2435306..2436448	+	1143	WP_054189923.1	glycerate kinase	-
L1O91_RS12015	2436508..2437161	+	654	WP_054189922.1	hypothetical protein	-
L1O91_RS12020	2437343..2438554	+	1212	WP_054189921.1	multidrug effflux MFS transporter	-
L1O91_RS12025	2438678..2439151	-	474	WP_054189920.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3984.75 Da
• Isoelectric Point: 11.0582

>T232655 WP_000482651.1 NZ_CP091066:c2434518-2434411 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRSNKKGDK

Nucleotide

• Length: 108 bp

>T232655 NZ_CP127856:1059115-1059384 [Pseudoalteromonas sp. JC3]
ATGAGTAGTAGTCAACGTTTACTGTCGTGGACTGATGACGCTTGGGATGACTATCTGTATTGGCAAACTCAAGACAAGAA
AACACTCAAGCGCATCAACAAACTCATCAATGATGTTAAGCGCTCCCCATTTGAGGGCATCGGTAAACCAGAGCCGTTGA
AAGAGAGTTTATCTGGTTTTTGGTCTCGTCGTATTGATGACACTAACAGGCTTGTTTATGCAGTTGATGATCAAGCGATA
ACGATAATTTCGTGTCGTTACCACTACTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT232655 NZ_CP091066:2434334-2434394 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTATTGCCGTAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2K4AFL5

Antitoxin