Detailed information of TA system TA232654

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2413417..2413934
• Replicon: chromosome
• Accession: NZ_CP091066
• Organism: Staphylococcus aureus strain UMCG579

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: L1O91_RS11875
• Protein ID: WP_054189942.1
• Coordinates: 2413417..2413683 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: L1O91_RS11880
• Protein ID: WP_054189941.1
• Coordinates: 2413683..2413934 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L1O91_RS11845 (2408622)	2408622..2409158	-	537	WP_054189946.1	GNAT family N-acetyltransferase	-
L1O91_RS11850 (2409627)	2409627..2410451	-	825	WP_000594640.1	formate/nitrite transporter family protein	-
L1O91_RS11855 (2410654)	2410654..2410836	-	183	WP_054189945.1	hypothetical protein	-
L1O91_RS11860 (2410923)	2410923..2411390	-	468	WP_054189944.1	SRPBCC domain-containing protein	-
L1O91_RS11865 (2411576)	2411576..2413123	-	1548	WP_054189943.1	zinc ABC transporter substrate-binding lipoprotein AdcA	-
L1O91_RS11870 (2413311)	2413311..2413382	-	72	WP_223200558.1	hypothetical protein	-
L1O91_RS11875 (2413417)	2413417..2413683	-	267	WP_054189942.1	Txe/YoeB family addiction module toxin	Toxin
L1O91_RS11880 (2413683)	2413683..2413934	-	252	WP_054189941.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
L1O91_RS11885 (2414099)	2414099..2414200	-	102	Protein_2293	hypothetical protein	-
L1O91_RS11890 (2414207)	2414207..2414806	-	600	WP_054189940.1	DsbA family protein	-
L1O91_RS11895 (2414825)	2414825..2415187	-	363	WP_054189939.1	DUF4467 domain-containing protein	-
L1O91_RS11900 (2415443)	2415443..2416693	+	1251	WP_054189938.1	FemA/FemB family glycyltransferase FmhA	-
L1O91_RS11905 (2416788)	2416788..2417519	-	732	WP_054189937.1	amino acid ABC transporter ATP-binding protein	-
L1O91_RS11910 (2417516)	2417516..2418235	-	720	WP_054189936.1	amino acid ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10393.94 Da
• Isoelectric Point: 10.0573

>T232654 WP_054189942.1 NZ_CP091066:c2413683-2413417 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMALKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Nucleotide

• Length: 267 bp

>T232654 NZ_CP127856:1058868-1059122 [Pseudoalteromonas sp. JC3]
ATGAGAATTGTATCTTTTACTGAAGCTAGAAATAGTCTTAAAGCTGTTCTAGACGGTGTAGTTAACGACGCAGATACAAC
AGTCATTACACGTCGTGACTCTGAGGATGCTGTGGTTATGTCTTTAGATTACTACAATAGCCTTATGGAGACTGTTCACT
TACTACGCTCTCCTCAAAACGCTGAACACTTAAATCGTTCGATTGCACAGTACCGTGCTGGTAAAACAACAGCACGAGAG
TTAATTGATGAGTAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9463.69 Da
• Isoelectric Point: 4.3407

>AT232654 WP_054189941.1 NZ_CP091066:c2413934-2413683 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTIMKD
IDV

Nucleotide

• Length: 252 bp

>AT232654 NZ_CP127856:1059115-1059384 [Pseudoalteromonas sp. JC3]
ATGAGTAGTAGTCAACGTTTACTGTCGTGGACTGATGACGCTTGGGATGACTATCTGTATTGGCAAACTCAAGACAAGAA
AACACTCAAGCGCATCAACAAACTCATCAATGATGTTAAGCGCTCCCCATTTGAGGGCATCGGTAAACCAGAGCCGTTGA
AAGAGAGTTTATCTGGTTTTTGGTCTCGTCGTATTGATGACACTAACAGGCTTGTTTATGCAGTTGATGATCAAGCGATA
ACGATAATTTCGTGTCGTTACCACTACTAA